ENSG00000267673


Homo sapiens

Features
Gene ID: ENSG00000267673
  
Biological name :FDX2
  
Synonyms : FDX2 / ferredoxin 2 / Q6P4F2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.2
Gene start: 10310045
Gene end: 10316015
  
Corresponding Affymetrix probe sets: 226451_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000377311
Ensembl peptide - ENSP00000488228
Ensembl peptide - ENSP00000467188
NCBI entrez gene - 112812     See in Manteia.
OMIM - 614585
RefSeq - NM_001031734
RefSeq Peptide - NP_001026904
swissprot - A0A0A0MTS8
swissprot - Q6P4F2
Ensembl - ENSG00000267673
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fdx1lENSDARG00000052190Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC011511.1ENSG0000016780773
FDX1 / P10109 / ferredoxin 1ENSG0000013771427


Protein motifs (from Interpro)
Interpro ID Name
 IPR001041  2Fe-2S ferredoxin-type iron-sulfur binding domain
 IPR001055  Adrenodoxin
 IPR012675  Beta-grasp domain superfamily
 IPR018298  Adrenodoxin, iron-sulphur binding site
 IPR036010  2Fe-2S ferredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006700 C21-steroid hormone biosynthetic process TAS
 biological_processGO:0016125 sterol metabolic process TAS
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0044281 small molecule metabolic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051537 2 iron, 2 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Mitochondrial iron-sulfur cluster biogenesis
Pregnenolone biosynthesis
Endogenous sterols
Electron transport from NADPH to Ferredoxin
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000137714 FDX1 / P10109 / ferredoxin 1  / reaction
 ENSG00000140459 P05108 / CYP11A1 / cytochrome P450 family 11 subfamily A member 1  / complex / reaction
 ENSG00000161513 FDXR / P22570 / ferredoxin reductase  / complex / reaction
 ENSG00000267673 FDX2 / Q6P4F2 / ferredoxin 2  / reaction






 

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