ENSMUSG00000019326


Mus musculus

Features
Gene ID: ENSMUSG00000019326
  
Biological name :Aoc3
  
Synonyms : Aoc3 / Membrane primary amine oxidase / O70423
  
Possible biological names infered from orthology : amine oxidase, copper containing 3 / Q16853
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 101330605
Gene end: 101341938
  
Corresponding Affymetrix probe sets: 10381371 (MoGene1.0st)   1449396_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099394
Ensembl peptide - ENSMUSP00000017316
NCBI entrez gene - 11754     See in Manteia.
MGI - MGI:1306797
RefSeq - NM_009675
RefSeq - XM_006532041
RefSeq Peptide - NP_033805
swissprot - A2A4I8
swissprot - O70423
Ensembl - ENSMUSG00000019326
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aoc2ENSDARG00000014646Danio rerio
 ENSGALG00000033522Gallus gallus
 ENSGALG00000046412Gallus gallus
 AOC3ENSG00000131471Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aoc2 / Q812C9 / Retina-specific copper amine oxidase / O75106* / amine oxidase, copper containing 2*ENSMUSG0000007865161
Aoc1 / P19801* / amine oxidase, copper containing 1*ENSMUSG0000002981139
Svs1 / seminal vesicle secretory protein 1 / AOC1* / P19801* / amine oxidase, copper containing 1*ENSMUSG0000003921532
Doxl2 / AOC1* / P19801* / amine oxidase, copper containing 1*ENSMUSG0000006853631
1600015I10Rik / RIKEN cDNA 1600015I10 gene / AOC1* / P19801* / amine oxidase, copper containing 1*ENSMUSG0000002981329


Protein motifs (from Interpro)
Interpro ID Name
 IPR000269  Copper amine oxidase
 IPR015798  Copper amine oxidase, catalytic domain
 IPR015800  Copper amine oxidase, N2-terminal
 IPR015802  Copper amine oxidase, N3-terminal
 IPR016182  Copper amine oxidase, N-terminal
 IPR036460  Copper amine oxidase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion ISO
 biological_processGO:0009308 amine metabolic process IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1902283 negative regulation of primary amine oxidase activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008131 primary amine oxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0048038 quinone binding IEA
 molecular_functionGO:0052593 tryptamine:oxygen oxidoreductase (deaminating) activity IEA
 molecular_functionGO:0052594 aminoacetone:oxygen oxidoreductase(deaminating) activity IEA
 molecular_functionGO:0052595 aliphatic-amine oxidase activity IEA
 molecular_functionGO:0052596 phenethylamine:oxygen oxidoreductase (deaminating) activity IEA


Pathways (from Reactome)
Pathway description
Phase I - Functionalization of compounds


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mchr1tm1Dgam/Mchr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Mchr1tm1Dgam/Mchr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Mchr1tm1Dgam/Mchr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
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Allelic Composition: Mchr1tm1Dgam/Mchr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Mchr1tm1Dgam/Mchr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019326 Aoc3 / O70423 / Membrane primary amine oxidase / Q16853* / amine oxidase, copper containing 3*  / complex






 

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