ENSMUSG00000019373


Mus musculus

Features
Gene ID: ENSMUSG00000019373
  
Biological name :Cops3
  
Synonyms : COP9 signalosome complex subunit 3 / Cops3 / O88543
  
Possible biological names infered from orthology : COP9 signalosome subunit 3 / Q9UNS2
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 59817795
Gene end: 59839838
  
Corresponding Affymetrix probe sets: 10386442 (MoGene1.0st)   1416678_at (Mouse Genome 430 2.0 Array)   1441156_at (Mouse Genome 430 2.0 Array)   1443570_at (Mouse Genome 430 2.0 Array)   1449785_at (Mouse Genome 430 2.0 Array)   1458259_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120305
Ensembl peptide - ENSMUSP00000019517
Ensembl peptide - ENSMUSP00000117288
NCBI entrez gene - 26572     See in Manteia.
MGI - MGI:1349409
RefSeq - NM_011991
RefSeq - XM_006533383
RefSeq Peptide - NP_036121
swissprot - F6YCA7
swissprot - O88543
swissprot - Q3UQL2
swissprot - D3Z036
Ensembl - ENSMUSG00000019373
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cops3ENSDARG00000008623Danio rerio
 COPS3ENSGALG00000004834Gallus gallus
 COPS3ENSG00000141030Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000717  Proteasome component (PCI) domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000338 protein deneddylation IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0008180 COP9 signalosome IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Hrh3+/?
Genetic Background: B10.S-H2s/SgMcdJ

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011197 abnormal proamniotic cavity morphology "any structural anomaly of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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