ENSMUSG00000019433


Mus musculus

Features
Gene ID: ENSMUSG00000019433
  
Biological name :Gipc1
  
Synonyms : Gipc1 / PDZ domain-containing protein GIPC1 / Q9Z0G0
  
Possible biological names infered from orthology : GIPC PDZ domain containing family member 1 / O14908
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C2
Gene start: 83652677
Gene end: 83664694
  
Corresponding Affymetrix probe sets: 10573203 (MoGene1.0st)   1422763_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019577
Ensembl peptide - ENSMUSP00000148847
Ensembl peptide - ENSMUSP00000148824
NCBI entrez gene - 67903     See in Manteia.
MGI - MGI:1926252
RefSeq - NM_018771
RefSeq Peptide - NP_061241
swissprot - A0A1D5RMN2
swissprot - A0A1D5RML2
swissprot - Q9Z0G0
Ensembl - ENSMUSG00000019433
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gipc1ENSDARG00000104483Danio rerio
 GIPC1ENSG00000123159Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gipc2 / Q9Z2H7 / PDZ domain-containing protein GIPC2 / Q8TF65* / GIPC PDZ domain containing family member 2*ENSMUSG0000003913161
Gipc3 / Q8R5M0 / PDZ domain-containing protein GIPC3 / Q8TF64* / GIPC PDZ domain containing family member 3*ENSMUSG0000003487256


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR017379  PDZ domain-containing protein GIPC1/2/3
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting IPI
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0014047 glutamate secretion IMP
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0031647 regulation of protein stability IDA
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0032467 positive regulation of cytokinesis IEA
 biological_processGO:0043542 endothelial cell migration IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048167 regulation of synaptic plasticity IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005903 brush border IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0012506 vesicle membrane IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0043198 dendritic shaft IDA
 molecular_functionGO:0003779 actin binding IPI
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017022 myosin binding IPI
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col4a4bwk/Col4a4bwk
Genetic Background: 129S1.NON(NZO)-Col4a4bwk/PgnJ

Allelic Composition: Gipc1tm1.1Mhsi/Gipc1tm1.1Mhsi,Tg(Cdh5-cre/ERT2)1Rha/?
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJaeSor * C57BL/6

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Nefhtm1Jpj/Nefhtm1Jpj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J

 MP:0003394 increased cardiac output "greater than normal blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J

 MP:0010477 coronary artery aneurysm "a protruding sac formed by the dilation of the wall of a coronary artery resulting from a weakening of the vessel wall" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col4a4bwk/Col4a4bwk
Genetic Background: 129S1.NON(NZO)-Col4a4bwk/PgnJ

 MP:0011655 abnormal systemic artery morphology "any structural anomaly of the arteries that carry oxygenated blood away from the heart to the body, as opposed to the pulmonary arteries, which carry deoxygenated blood to the lungs" [MGI:csmith]
Show

Allelic Composition: Col4a4bwk/Col4a4bwk
Genetic Background: 129S1.NON(NZO)-Col4a4bwk/PgnJ

Allelic Composition: Gipc1tm1.1Mhsi/Gipc1tm1.1Mhsi,Tg(Tek-cre)12Flv/?
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJaeSor * C3H * C57BL/6

Allelic Composition: Gipc1tm1.1Mhsi/Gipc1tm1.1Mhsi,Tg(Cdh5-cre/ERT2)1Rha/?
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJaeSor * C57BL/6

 MP:0011952 decreased cardiac stroke volume "reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
Show

Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr