ENSMUSG00000019590


Mus musculus

Features
Gene ID: ENSMUSG00000019590
  
Biological name :Cyb561
  
Synonyms : Cyb561 / Cytochrome b561 / Q60720
  
Possible biological names infered from orthology : P49447
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 105933702
Gene end: 105953336
  
Corresponding Affymetrix probe sets: 10392056 (MoGene1.0st)   1417507_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139125
Ensembl peptide - ENSMUSP00000138889
Ensembl peptide - ENSMUSP00000138931
Ensembl peptide - ENSMUSP00000019734
Ensembl peptide - ENSMUSP00000121990
Ensembl peptide - ENSMUSP00000138838
NCBI entrez gene - 13056     See in Manteia.
MGI - MGI:103253
RefSeq - XM_006532134
RefSeq - NM_007805
RefSeq - XM_006532130
RefSeq - XM_006532131
RefSeq - XM_006532132
RefSeq - XM_006532133
RefSeq Peptide - NP_001343303
RefSeq Peptide - NP_031831
swissprot - V9GXF4
swissprot - A2A685
swissprot - Q60720
swissprot - V9GWY3
swissprot - V9GWU6
swissprot - V9GX11
Ensembl - ENSMUSG00000019590
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyb561ENSDARG00000038176Danio rerio
 CYB561ENSGALG00000024031Gallus gallus
 CYB561ENSG00000008283Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6P1H1 / Cyb561a3 / Cytochrome b ascorbate-dependent protein 3 / Q8NBI2* / cytochrome b561 family member A3*ENSMUSG0000003444538
Cybrd1 / Q925G2 / Cytochrome b reductase 1 / Q53TN4*ENSMUSG0000002701535


Protein motifs (from Interpro)
Interpro ID Name
 IPR006593  Cytochrome b561/ferric reductase transmembrane
 IPR028837  Cytochrome b561


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005765 lysosomal membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0000293 ferric-chelate reductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0004129 abnormal respiratory quotient "anomaly in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism" [J:94416]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
Show

Allelic Composition: Ctsktm1b(EUCOMM)Hmgu/Ctsktm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ctsktm1b(EUCOMM)Hmgu/Tcp

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0006241 abnormal placement of pupils "abnormal location of the pupil so that it is not in the center of the iris" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0008806 increased circulating amylase level "greater concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066]
Show

Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0010087 increased circulating fructosamine level "increase in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0010092 increased circulating magnesium level "an elevation in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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