Manteia - Molecule gene

ENSMUSG00000019787

Mus musculus

Features

Gene ID:	ENSMUSG00000019787

Biological name :	Trdn

Synonyms :	E9Q9K5 / Trdn / Triadin

Possible biological names infered from orthology :	Q13061

Species:	Mus musculus

Chr. number:	10
Strand:	1
Band:	A4
Gene start:	33080554
Gene end:	33476709

Corresponding Affymetrix probe sets:	10362404 (MoGene1.0st) 10362416 (MoGene1.0st) 10362418 (MoGene1.0st) 10362420 (MoGene1.0st) 10362422 (MoGene1.0st) 10362424 (MoGene1.0st) 10362426 (MoGene1.0st) 10362428 (MoGene1.0st) 10362432 (MoGene1.0st) 10362434 (MoGene1.0st) 10362436 (MoGene1.0st) 10362440 (MoGene1.0st) 10362442 (MoGene1.0st) 10362446 (MoGene1.0st) 10362450 (MoGene1.0st) 10362454 (MoGene1.0st) 10362456 (MoGene1.0st) 10362458 (MoGene1.0st) 10362462 (MoGene1.0st) 1426134_at (Mouse Genome 430 2.0 Array) 1426142_a_at (Mouse Genome 430 2.0 Array) 1426143_at (Mouse Genome 430 2.0 Array) 1426144_x_at (Mouse Genome 430 2.0 Array) 1451801_at (Mouse Genome 430 2.0 Array) 1451940_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000151565 Ensembl peptide - ENSMUSP00000152047 Ensembl peptide - ENSMUSP00000152042 Ensembl peptide - ENSMUSP00000151999 Ensembl peptide - ENSMUSP00000151583 Ensembl peptide - ENSMUSP00000093436 Ensembl peptide - ENSMUSP00000151235 NCBI entrez gene - 76757 See in Manteia. MGI - MGI:1924007 RefSeq - NM_029726 RefSeq Peptide - NP_084002 swissprot - E9Q9K5 swissprot - A0A1W2P6F3 swissprot - A0A1W2P8G7 swissprot - A0A1W2P7C3 Ensembl - ENSMUSG00000019787

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
trdn	ENSDARG00000041779	Danio rerio
TRDN	ENSGALG00000014848	Gallus gallus
TRDN	ENSG00000186439	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR007943	Aspartyl beta-hydroxylase/Triadin domain
IPR010798	Triadin

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006936	muscle contraction	IBA
biological_process	GO:0010649	regulation of cell communication by electrical coupling	IBA
biological_process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IBA
biological_process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IMP
biological_process	GO:0060047	heart contraction	ISO
biological_process	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity	IBA
biological_process	GO:0086036	regulation of cardiac muscle cell membrane potential	IBA
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0005886	plasma membrane	IBA
cellular_component	GO:0014701	junctional sarcoplasmic reticulum membrane	IBA
cellular_component	GO:0016020	membrane	TAS
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0016529	sarcoplasmic reticulum	IEA
cellular_component	GO:0033017	sarcoplasmic reticulum membrane	IEA
molecular_function	GO:0005102	signaling receptor binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0044325	ion channel binding	IBA

Pathways (from Reactome)

Pathway description

Stimuli-sensing channels

Ion homeostasis

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002106	abnormal muscle physiology	"anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ptk2^tm1Heen/Ptk2^tm1Heen Genetic Background: involves: 129/Sv * C57BL/6
MP:0004088	abnormal sarcoplasmic reticulum morphology	"any structural abnormality in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Ptk2^tm1Heen/Ptk2^tm1Heen Genetic Background: involves: 129/Sv * C57BL/6
MP:0004145	abnormal muscle electrophysiology	"anomaly in the function of the musculature as it relates to electrical phenomena" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ptk2^tm1Heen/Ptk2^tm1Heen Genetic Background: involves: 129/Sv * C57BL/6
MP:0009411	abnormal skeletal muscle fiber triad morphology	"any structural anomaly of the skeletal muscle fiber structure comprised of the transverse tubule and the two associated terminal cisternae; each fiber normally has thousands of triads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Errfi1^tm1.1Jwj/Errfi1^tm1.1Jwj Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL Allelic Composition: Trdn^tm1.2Isma/Trdn^tm1.2Isma Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0009461	skeletal muscle hypertrophy	"increase in the bulk size of the skeletal muscle due to cell enlargement" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Trdn^tm1.2Isma/Trdn^tm1.2Isma Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Trdn^tm1.2Isma/Trdn^tm1.2Isma Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr