ENSMUSG00000019809


Mus musculus

Features
Gene ID: ENSMUSG00000019809
  
Biological name :Pex3
  
Synonyms : Peroxisomal biosis factor 3 / Pex3 / Q9QXY9
  
Possible biological names infered from orthology : P56589 / peroxisomal biogenesis factor 3
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A2
Gene start: 13523842
Gene end: 13553142
  
Corresponding Affymetrix probe sets: 10367960 (MoGene1.0st)   1417442_a_at (Mouse Genome 430 2.0 Array)   1454044_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101178
Ensembl peptide - ENSMUSP00000128512
Ensembl peptide - ENSMUSP00000101180
Ensembl peptide - ENSMUSP00000019945
NCBI entrez gene - 56535     See in Manteia.
MGI - MGI:1929646
RefSeq - NM_001164195
RefSeq - XM_006512807
RefSeq - NM_019961
RefSeq Peptide - NP_001157667
RefSeq Peptide - NP_001334290
RefSeq Peptide - NP_064345
swissprot - Q9QXY9
swissprot - D3Z6X4
swissprot - Q3UIG2
swissprot - D3Z6X3
swissprot - E9QA46
Ensembl - ENSMUSG00000019809
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pex3ENSDARG00000013973Danio rerio
 PEX3ENSGALG00000013777Gallus gallus
 PEX3ENSG00000034693Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006966  Peroxin-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007031 peroxisome organization IEA
 biological_processGO:0016557 peroxisome membrane biogenesis IEA
 biological_processGO:0045046 protein import into peroxisome membrane IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005777 peroxisome ISO
 cellular_componentGO:0005778 peroxisomal membrane IEA
 cellular_componentGO:0005779 integral component of peroxisomal membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0032994 protein-lipid complex ISO
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
ABC transporters in lipid homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000647 abnormal sebaceous gland morphology "malformation of the holocrine glands of the dermis that secrete sebum into the hair follicles" [MGI:tc]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002697 abnormal eye size "anomalous bulk of the organ of vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0009759 abnormal hair follicle bulge "an anomaly in the area located in the bottom of the permanent portion of a resting (telogen) hair follicle where the cells of the external root sheath of the hair follicle are contiguous with the basal layer of the epidermis; this portion of the follicle is involved in the generation of a new hair at the onset of the hair growth cycle (anagen)" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010087 increased circulating fructosamine level "increase in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010088 decreased circulating fructosamine level "decrease in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0012725 small sebaceous gland "decreased size of the sebum secreting glands of the hair shaft" [MGI:mnk]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031378 Abcd1 / P48410 / ATP-binding cassette, sub-family D (ALD), member 1 / P33897* / ATP binding cassette subfamily D member 1*  / reaction
 ENSMUSG00000028127 Abcd3 / P55096 / ATP-binding cassette, sub-family D (ALD), member 3 / P28288* / ATP binding cassette subfamily D member 3*  / reaction
 ENSMUSG00000055782 Abcd2 / ATP-binding cassette, sub-family D (ALD), member 2 / Q9UBJ2* / ATP binding cassette subfamily D member 2*  / reaction
 ENSMUSG00000003464 Pex19 / Q8VCI5 / Peroxisomal biosis factor 19 / P40855* / peroxisomal biogenesis factor 19*  / reaction






 

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