ENSMUSG00000055782


Mus musculus

Features
Gene ID: ENSMUSG00000055782
  
Biological name :Abcd2
  
Synonyms : Abcd2 / ATP-binding cassette, sub-family D (ALD), member 2
  
Possible biological names infered from orthology : ATP binding cassette subfamily D member 2 / Q9UBJ2
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E3
Gene start: 91145871
Gene end: 91191799
  
Corresponding Affymetrix probe sets: 10431697 (MoGene1.0st)   1419748_at (Mouse Genome 430 2.0 Array)   1438431_at (Mouse Genome 430 2.0 Array)   1439835_x_at (Mouse Genome 430 2.0 Array)   1456812_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068940
NCBI entrez gene - 26874     See in Manteia.
MGI - MGI:1349467
RefSeq - XM_006521017
RefSeq - NM_001358967
RefSeq - NM_011994
RefSeq Peptide - NP_001345896
RefSeq Peptide - NP_036124
swissprot - A0A0R4J0U5
Ensembl - ENSMUSG00000055782
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcd2ENSDARG00000059409Danio rerio
 ABCD2ENSGALG00000042554Gallus gallus
 ABCD2ENSG00000173208Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcd1 / P48410 / ATP-binding cassette, sub-family D (ALD), member 1 / P33897* / ATP binding cassette subfamily D member 1*ENSMUSG0000003137863
Abcd3 / P55096 / ATP-binding cassette, sub-family D (ALD), member 3 / P28288* / ATP binding cassette subfamily D member 3*ENSMUSG0000002812734
Abcd4 / O89016 / ATP-binding cassette, sub-family D (ALD), member 4 / O14678* / ATP binding cassette subfamily D member 4*ENSMUSG0000002124021


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031239  ATP-binding cassette sub-family D member 2
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000038 very long-chain fatty acid metabolic process IEA
 biological_processGO:0006635 fatty acid beta-oxidation IEA
 biological_processGO:0032000 positive regulation of fatty acid beta-oxidation IEA
 biological_processGO:0042760 very long-chain fatty acid catabolic process IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
ABC transporters in lipid homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
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Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0003492 abnormal involuntary movement "anomalies in movements that occur independent of planning (eg. reflexive behavior)" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcd1tm1Kds/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0008288 abnormal adrenal cortex morphology "any structural anomaly of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcd1tm1Kds/Y,Abcd2tm1Apuj/Abcd2tm1Apuj
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031378 Abcd1 / P48410 / ATP-binding cassette, sub-family D (ALD), member 1 / P33897* / ATP binding cassette subfamily D member 1*  / complex
 ENSMUSG00000019809 Pex3 / Q9QXY9 / Peroxisomal biosis factor 3 / P56589* / peroxisomal biogenesis factor 3*  / reaction
 ENSMUSG00000003464 Pex19 / Q8VCI5 / Peroxisomal biosis factor 19 / P40855* / peroxisomal biogenesis factor 19*  / complex
 ENSMUSG00000028127 Abcd3 / P55096 / ATP-binding cassette, sub-family D (ALD), member 3 / P28288* / ATP binding cassette subfamily D member 3*  / complex






 

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