Manteia

ENSMUSG00000028127

Mus musculus

Features

Gene ID:	ENSMUSG00000028127

Biological name :	Abcd3

Synonyms :	Abcd3 / ATP-binding cassette, sub-family D (ALD), member 3 / P55096

Possible biological names infered from orthology :	ATP binding cassette subfamily D member 3 / P28288

Species:	Mus musculus

Chr. number:	3
Strand:	-1
Band:	G1
Gene start:	121758774
Gene end:	121815302

Corresponding Affymetrix probe sets:	10501832 (MoGene1.0st) 1416679_at (Mouse Genome 430 2.0 Array) 1443046_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000142387 Ensembl peptide - ENSMUSP00000143487 Ensembl peptide - ENSMUSP00000029770 NCBI entrez gene - 19299 See in Manteia. MGI - MGI:1349216 RefSeq - NM_008991 RefSeq - XM_006501152 RefSeq - NM_001355756 RefSeq Peptide - NP_001342685 RefSeq Peptide - NP_033017 swissprot - A0A0G2JDI9 swissprot - P55096 swissprot - A0A0G2JGA4 Ensembl - ENSMUSG00000028127

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
abcd3a	ENSDARG00000104085	Danio rerio
abcd3b	ENSDARG00000002947	Danio rerio
ABCD3	ENSGALG00000005647	Gallus gallus
ABCD3	ENSG00000117528	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Abcd2 / ATP-binding cassette, sub-family D (ALD), member 2 / Q9UBJ2* / ATP binding cassette subfamily D member 2*	ENSMUSG00000055782	39
Abcd1 / P48410 / ATP-binding cassette, sub-family D (ALD), member 1 / P33897* / ATP binding cassette subfamily D member 1*	ENSMUSG00000031378	38
Abcd4 / O89016 / ATP-binding cassette, sub-family D (ALD), member 4 / O14678* / ATP binding cassette subfamily D member 4*	ENSMUSG00000021240	25

Protein motifs (from Interpro)

Interpro ID	Name
IPR003439	ABC transporter-like
IPR003593	AAA+ ATPase domain
IPR005283	Peroxysomal long chain fatty acyl transporter
IPR011527	ABC transporter type 1, transmembrane domain
IPR017871	ABC transporter, conserved site
IPR027417	P-loop containing nucleoside triphosphate hydrolase
IPR031241	ATP-binding cassette sub-family D member 3
IPR036640	ABC transporter type 1, transmembrane domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006633	fatty acid biosynthetic process	IEA
biological_process	GO:0006635	fatty acid beta-oxidation	IEA
biological_process	GO:0007031	peroxisome organization	IEA
biological_process	GO:0014070	response to organic cyclic compound	IEA
biological_process	GO:0015910	peroxisomal long-chain fatty acid import	IEA
biological_process	GO:0042493	response to drug	IEA
biological_process	GO:0042760	very long-chain fatty acid catabolic process	IEA
biological_process	GO:0055085	transmembrane transport	IEA
cellular_component	GO:0005739	mitochondrion	IEA
cellular_component	GO:0005743	mitochondrial inner membrane	IDA
cellular_component	GO:0005777	peroxisome	ISO
cellular_component	GO:0005778	peroxisomal membrane	ISO
cellular_component	GO:0005782	peroxisomal matrix	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0005324	long-chain fatty acid transporter activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	ISO
molecular_function	GO:0016887	ATPase activity	ISO
molecular_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	IEA
molecular_function	GO:0042803	protein homodimerization activity	ISO
molecular_function	GO:0043621	protein self-association	IEA

Pathways (from Reactome)

Pathway description

ABC transporters in lipid homeostasis

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000358	abnormal cell content/ morphology	"structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Alx4^Lst-2J/Alx4⁺ Genetic Background: C57BL/6J-Alx4^Lst-2J/J
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Alx4^Lst-2J/Alx4⁺ Genetic Background: C57BL/6J-Alx4^Lst-2J/J
MP:0004773	abnormal bile composition	"any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Alx4^Lst-2J/Alx4⁺ Genetic Background: C57BL/6J-Alx4^Lst-2J/J
MP:0009642	abnormal blood homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Alx4^Lst-2J/Alx4⁺ Genetic Background: C57BL/6J-Alx4^Lst-2J/J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000031378	Abcd1 / P48410 / ATP-binding cassette, sub-family D (ALD), member 1 / P33897* / ATP binding cassette subfamily D member 1*	/ complex
ENSMUSG00000003464	Pex19 / Q8VCI5 / Peroxisomal biosis factor 19 / P40855* / peroxisomal biogenesis factor 19*	/ complex
ENSMUSG00000019809	Pex3 / Q9QXY9 / Peroxisomal biosis factor 3 / P56589* / peroxisomal biogenesis factor 3*	/ reaction
ENSMUSG00000055782	Abcd2 / ATP-binding cassette, sub-family D (ALD), member 2 / Q9UBJ2* / ATP binding cassette subfamily D member 2*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr