Manteia

ENSMUSG00000019817

Mus musculus

Features

Gene ID:	ENSMUSG00000019817

Biological name :	Plagl1

Synonyms :	Plagl1

Possible biological names infered from orthology :	PLAG1 like zinc finger 1 / Q9UM63

Species:	Mus musculus

Chr. number:	10
Strand:	1
Band:	A2
Gene start:	13060504
Gene end:	13131694

Corresponding Affymetrix probe sets:	10361771 (MoGene1.0st) 1426208_x_at (Mouse Genome 430 2.0 Array) 1438588_at (Mouse Genome 430 2.0 Array) 1450533_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000115595 Ensembl peptide - ENSMUSP00000141514 Ensembl peptide - ENSMUSP00000120581 Ensembl peptide - ENSMUSP00000117321 Ensembl peptide - ENSMUSP00000112847 Ensembl peptide - ENSMUSP00000112889 Ensembl peptide - ENSMUSP00000113710 NCBI entrez gene - 22634 See in Manteia. MGI - MGI:1100874 RefSeq - NM_009538 RefSeq Peptide - NP_033564 swissprot - Q3UQW2 swissprot - B0QZX5 swissprot - Q9JLQ4 swissprot - B0QZX4 swissprot - A0A0A6YWE3 Ensembl - ENSMUSG00000019817

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
PLAGL1	ENSGALG00000013754	Gallus gallus
PLAGL1	ENSG00000118495	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Plag1 / Q9QYE0 / Zinc finger protein PLAG1 / Q6DJT9* / PLAG1 zinc finger*	ENSMUSG00000003282	27
Plagl2 / PLAG1 like zinc finger 2 / Q9UPG8*	ENSMUSG00000051413	23

Protein motifs (from Interpro)

Interpro ID	Name
IPR013087	Zinc finger C2H2-type
IPR027770	Zinc finger protein PLAGL1
IPR036236	Zinc finger C2H2 superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0006915	apoptotic process	IBA
biological_process	GO:0010468	regulation of gene expression	IGI
biological_process	GO:0035914	skeletal muscle cell differentiation	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO
cellular_component	GO:0005634	nucleus	IBA
cellular_component	GO:0005794	Golgi apparatus	ISO
cellular_component	GO:0016604	nuclear body	ISO
cellular_component	GO:0043231	intracellular membrane-bounded organelle	ISO
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	ISO
molecular_function	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	IBA
molecular_function	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003677	DNA binding	ISO
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1⁺ Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1^{Gt(OST181461)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0001177	atelectasis	"collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cxcr2^tm1Mwm/Cxcr2^tm1Mwm,Tg(TRAMP)8247Ng/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6
MP:0001211	wrinkled skin	"irregular folds and/or indentations on the skin" [J:19212]	Show Allelic Composition: Cxcr2^tm1Mwm/Cxcr2^tm1Mwm,Tg(TRAMP)8247Ng/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1⁺ Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1^{Gt(OST181461)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Cxcr2^tm1Mwm/Cxcr2^tm1Mwm,Tg(TRAMP)8247Ng/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6
MP:0002080	prenatal lethality	"death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cacna1a^tm1.2Sher/Cacna1a^tm1.2Sher Genetic Background: involves: 129S4/SvJae
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Plagl1^tm1Jour/Plagl1⁺ Genetic Background: B6.129P2-Plagl1^tm1Jour Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1⁺ Genetic Background: involves: 129S5/SvEvBrd
MP:0002759	abnormal caudal vertebrae morphology	"malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]	Show Allelic Composition: Cxcr2^tm1Mwm/Cxcr2^tm1Mwm,Tg(TRAMP)8247Ng/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6
MP:0002834	decreased heart weight	"less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Cxcr2^tm1Mwm/Cxcr2^tm1Mwm,Tg(TRAMP)8247Ng/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6
MP:0003051	curly tail	"a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Cxcr2^tm1Mwm/Cxcr2^tm1Mwm,Tg(TRAMP)8247Ng/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1⁺ Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1^{Gt(OST181461)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0003122	maternal imprinting	"specific loci are inactivated during oogenesis and are not expressed in offspring" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Cxcr2^tm1Mwm/Cxcr2^tm1Mwm,Tg(TRAMP)8247Ng/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 Allelic Composition: Plagl1^tm1Jour/Plagl1⁺ Genetic Background: CBA.129P2-Plagl1^tm1Jour
MP:0003123	paternal imprinting	"specific loci are inactivated during spermatogenesis and are not expressed in offspring " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator, llw2:Linda Washburn, Mouse Genome Informatics Curator]	Show Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1⁺ Genetic Background: involves: 129S5/SvEvBrd
MP:0003720	abnormal neural tube closure	"abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]	Show Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1⁺ Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1^{Gt(OST181461)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0005109	abnormal talus morphology	"malformation of the bone that articlulates with the tibia and fibula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]	Show Allelic Composition: Cxcr2^tm1Mwm/Cxcr2^tm1Mwm,Tg(TRAMP)8247Ng/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6
MP:0005306	abnormal phalanx morphology	"aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cxcr2^tm1Mwm/Cxcr2^tm1Mwm,Tg(TRAMP)8247Ng/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6
MP:0008271	abnormal bone ossification	"any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]	Show Allelic Composition: Cxcr2^tm1Mwm/Cxcr2^tm1Mwm,Tg(TRAMP)8247Ng/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1⁺ Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1^{Gt(OST181461)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0009431	decreased fetal weight	"reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cxcr2^tm1Mwm/Cxcr2^tm1Mwm,Tg(TRAMP)8247Ng/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6
MP:0009674	decreased birth weight	"reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]	Show Allelic Composition: Cxcr2^tm1Mwm/Cxcr2^tm1Mwm,Tg(TRAMP)8247Ng/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 Allelic Composition: Plagl1^tm1Jour/Plagl1⁺ Genetic Background: B6.129P2-Plagl1^tm1Jour Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1⁺ Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1^{Gt(OST181461)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0010403	atrial septal defect	"abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]	Show Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1⁺ Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1^{Gt(OST181461)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0010420	muscular ventricular septal defect	"abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]	Show Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1⁺ Genetic Background: involves: 129S5/SvEvBrd Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1^{Gt(OST181461)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Plagl1^tm1Jour/Plagl1⁺ Genetic Background: B6.129P2-Plagl1^tm1Jour Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1^{Gt(OST181461)Lex} Genetic Background: involves: 129S5/SvEvBrd
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Plagl1^tm1Jour/Plagl1⁺ Genetic Background: B6.129P2-Plagl1^tm1Jour
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Plagl1^{Gt(OST181461)Lex}/Plagl1^{Gt(OST181461)Lex} Genetic Background: involves: 129S5/SvEvBrd

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr