ENSMUSG00000051413


Mus musculus

Features
Gene ID: ENSMUSG00000051413
  
Biological name :Plagl2
  
Synonyms : PLAG1 like zinc finger 2 / Plagl2
  
Possible biological names infered from orthology : Q9UPG8
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H1
Gene start: 153227759
Gene end: 153241426
  
Corresponding Affymetrix probe sets: 10488697 (MoGene1.0st)   1417517_at (Mouse Genome 430 2.0 Array)   1417518_at (Mouse Genome 430 2.0 Array)   1417519_at (Mouse Genome 430 2.0 Array)   1442235_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055709
Ensembl peptide - ENSMUSP00000105419
NCBI entrez gene - 54711     See in Manteia.
MGI - MGI:1933165
RefSeq - NM_018807
RefSeq Peptide - NP_061277
swissprot - Q925T4
Ensembl - ENSMUSG00000051413
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plagxENSDARG00000036855Danio rerio
 PLAGL2ENSGALG00000006586Gallus gallus
 PLAGL2ENSG00000126003Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plag1 / Q9QYE0 / Zinc finger protein PLAG1 / Q6DJT9* / PLAG1 zinc finger*ENSMUSG0000000328243
Plagl1 / Q9UM63* / PLAG1 like zinc finger 1*ENSMUSG0000001981732


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0034378 chylomicron assembly IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Vezttm1.1Smc/Vezt+
Genetic Background: either: (involves: 129S2/SvPas * BALB/c * C57BL/6 * MF1) or (involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6N * MF1)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Vezttm1.1Smc/Vezt+
Genetic Background: either: (involves: 129S2/SvPas * BALB/c * C57BL/6 * MF1) or (involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6N * MF1)

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Vezttm1.1Smc/Vezt+
Genetic Background: either: (involves: 129S2/SvPas * BALB/c * C57BL/6 * MF1) or (involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6N * MF1)

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vezttm1.1Smc/Vezt+
Genetic Background: either: (involves: 129S2/SvPas * BALB/c * C57BL/6 * MF1) or (involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6N * MF1)

 MP:0005342 abnormal lipid absorption "anomalous ability of the body to take in fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Vezttm1.1Smc/Vezt+
Genetic Background: either: (involves: 129S2/SvPas * BALB/c * C57BL/6 * MF1) or (involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6N * MF1)

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vezttm1.1Smc/Vezt+
Genetic Background: either: (involves: 129S2/SvPas * BALB/c * C57BL/6 * MF1) or (involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6N * MF1)

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Vezttm1.1Smc/Vezt+
Genetic Background: either: (involves: 129S2/SvPas * BALB/c * C57BL/6 * MF1) or (involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6N * MF1)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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