| MP:0000607 | abnormal hepatocyte morphology | "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r
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| MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r
|
| MP:0000746 | weakness | "state of being infirm or less strong than littermates" [J:45400] |
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r
|
| MP:0000774 | reduced brain size | "smaller appearance of the brain" [J:35802] |
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r
|
| MP:0000781 | reduced size of corpus callosum | "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r
|
| MP:0000788 | abnormal cerebral cortex morphology | "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r
|
| MP:0000913 | abnormal brain development | "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840] |
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r
|
| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: NZW
|
| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r
|
| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r
|
| MP:0001364 | decreased anxiety-related response | "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043] |
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: NZW
|
| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: NZW
|
| MP:0001458 | abnormal object recognition memory | "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: NZW
|
| MP:0001463 | abnormal spatial learning | "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: NZW
Allelic Composition: Wasf1tm2Jsco/Wasf1tm2Jsco
Genetic Background: involves: 129X1/SvJ * C57BL/6
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| MP:0001475 | reduced long term depression | "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3] |
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: NZW
|
| MP:0001525 | impaired balance | "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123] |
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: NZW
|
| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r
|
| MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: NZW
|
| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r
|
| MP:0002206 | abnormal CNS synaptic transmission | "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: NZW
|
| MP:0002882 | abnormal neuron | "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: NZW
Allelic Composition: Wasf1tm2Jsco/Wasf1tm2Jsco
Genetic Background: involves: 129X1/SvJ * C57BL/6
|
| MP:0002888 | abnormal NMDA-mediated synaptic currents | "change in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: NZW
|
| MP:0002912 | abnormal excitatory postsynaptic potential | "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: NZW
Allelic Composition: Wasf1tm2Jsco/Wasf1tm2Jsco
Genetic Background: involves: 129X1/SvJ * C57BL/6
|
| MP:0003008 | enhanced long term potentiation | "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922] |
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: NZW
Allelic Composition: Wasf1tm2Jsco/Wasf1tm2Jsco
Genetic Background: involves: 129X1/SvJ * C57BL/6
|
| MP:0003461 | abnormal response to novel object | "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University] |
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Allelic Composition: Wasf1tm2Jsco/Wasf1tm2Jsco
Genetic Background: involves: 129X1/SvJ * C57BL/6
|
| MP:0004811 | abnormal neuron physiology | "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings] |
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: NZW
|
| MP:0005449 | abnormal food intake | "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r
|
| MP:0006254 | thin cerebral cortex | "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683] |
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r
|
| MP:0008109 | abnormal small intestinal microvillus morphology | "any structural anomaly of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r
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| MP:0008535 | enlarged lateral ventricles | "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r
|
| MP:0009413 | skeletal muscle fiber atrophy | "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r
|
| MP:0012468 | decreased striatum area | "reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343, MGI:csmith] |
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r
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| MP:0012489 | abnormal retrosplenial region morphology | "any structural anomaly of one of the key brain regions required for cognitive functions, including episodic memory, navigation, imagination and planning for the future; the retrosplenial region can be divided into three parts, the retrosplenial granular cortex A, the retrosplenial granular cortex B and the retrosplenial dysgranular cortex; each subdivision of the retrosplenial cortex projects to a discrete terminal field in the hippocampal formation" [PMID:1308170, PMID:19812579] |
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Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r
|
