ENSG00000112290


Homo sapiens

Features
Gene ID: ENSG00000112290
  
Biological name :WASF1
  
Synonyms : Q92558 / WASF1 / WAS protein family member 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q21
Gene start: 110099819
Gene end: 110180004
  
Corresponding Affymetrix probe sets: 204165_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000407041
Ensembl peptide - ENSP00000265601
Ensembl peptide - ENSP00000352425
Ensembl peptide - ENSP00000357934
Ensembl peptide - ENSP00000402663
Ensembl peptide - ENSP00000404142
Ensembl peptide - ENSP00000376365
Ensembl peptide - ENSP00000376366
Ensembl peptide - ENSP00000376367
Ensembl peptide - ENSP00000376368
NCBI entrez gene - 8936     See in Manteia.
OMIM - 605035
RefSeq - XM_017011444
RefSeq - NM_001024934
RefSeq - NM_001024935
RefSeq - NM_001024936
RefSeq - NM_003931
RefSeq - XM_011536235
RefSeq - XM_017011437
RefSeq - XM_017011438
RefSeq - XM_017011439
RefSeq - XM_017011440
RefSeq - XM_017011441
RefSeq - XM_017011442
RefSeq - XM_017011443
RefSeq - XM_005267203
RefSeq - XM_005267205
RefSeq - XM_005267206
RefSeq - XM_005267207
RefSeq - XM_011536233
RefSeq - XM_011536234
RefSeq Peptide - NP_001020106
RefSeq Peptide - NP_001020107
RefSeq Peptide - NP_003922
RefSeq Peptide - NP_001020105
swissprot - Q5SZK4
swissprot - Q5SZK5
swissprot - Q92558
swissprot - Q5SZK3
Ensembl - ENSG00000112290
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wasf1ENSDARG00000060349Danio rerio
 WASF1ENSGALG00000015066Gallus gallus
 Wasf1ENSMUSG00000019831Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WASF2 / Q9Y6W5 / WAS protein family member 2ENSG0000015819546
WASF3 / Q9UPY6 / WAS protein family member 3ENSG0000013297045


Protein motifs (from Interpro)
Interpro ID Name
 IPR003124  WH2 domain
 IPR028288  SCAR/WAVE family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0016601 Rac protein signal transduction IMP
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030041 actin filament polymerization TAS
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway IEA
 biological_processGO:0065003 protein-containing complex assembly NAS
 biological_processGO:0072673 lamellipodium morphogenesis IEA
 biological_processGO:0097484 dendrite extension IEA
 biological_processGO:1990416 cellular response to brain-derived neurotrophic factor stimulus IEA
 biological_processGO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005856 cytoskeleton TAS
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0015629 actin cytoskeleton TAS
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031209 SCAR complex IMP
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044877 protein-containing complex binding IMP
 molecular_functionGO:0048365 Rac GTPase binding IMP
 molecular_functionGO:0051018 protein kinase A binding IPI


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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