ENSG00000158195


Homo sapiens

Features
Gene ID: ENSG00000158195
  
Biological name :WASF2
  
Synonyms : Q9Y6W5 / WASF2 / WAS protein family member 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.11
Gene start: 27404226
Gene end: 27490158
  
Corresponding Affymetrix probe sets: 221725_at (Human Genome U133 Plus 2.0 Array)   224562_at (Human Genome U133 Plus 2.0 Array)   224563_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000439883
Ensembl peptide - ENSP00000483313
NCBI entrez gene - 10163     See in Manteia.
OMIM - 605875
RefSeq - NM_001201404
RefSeq - NM_006990
RefSeq Peptide - NP_001188333
RefSeq Peptide - NP_008921
swissprot - Q9Y6W5
Ensembl - ENSG00000158195
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wasf2ENSDARG00000024209Danio rerio
 WASF2ENSGALG00000014012Gallus gallus
 Wasf2ENSMUSG00000028868Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WASF1 / Q92558 / WAS protein family member 1ENSG0000011229052
WASF3 / Q9UPY6 / WAS protein family member 3ENSG0000013297050


Protein motifs (from Interpro)
Interpro ID Name
 IPR003124  WH2 domain
 IPR028288  SCAR/WAVE family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001667 ameboidal-type cell migration IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0010592 positive regulation of lamellipodium assembly IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016601 Rac protein signal transduction IEA
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0030036 actin cytoskeleton organization TAS
 biological_processGO:0030048 actin filament-based movement IEA
 biological_processGO:0035855 megakaryocyte development IEA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0051497 negative regulation of stress fiber assembly IMP
 biological_processGO:0072673 lamellipodium morphogenesis IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0015629 actin cytoskeleton TAS
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0031209 SCAR complex IMP
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003779 actin binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IPI
 molecular_functionGO:0044877 protein-containing complex binding IMP
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0051018 protein kinase A binding IPI


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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