ENSMUSG00000028868


Mus musculus

Features
Gene ID: ENSMUSG00000028868
  
Biological name :Wasf2
  
Synonyms : Q8BH43 / Wasf2 / WAS protein family, member 2
  
Possible biological names infered from orthology : Q9Y6W5
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.3
Gene start: 133130505
Gene end: 133199756
  
Corresponding Affymetrix probe sets: 10508805 (MoGene1.0st)   1438683_at (Mouse Genome 430 2.0 Array)   1454673_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081263
Ensembl peptide - ENSMUSP00000101532
Ensembl peptide - ENSMUSP00000117314
NCBI entrez gene - 242687     See in Manteia.
MGI - MGI:1098641
RefSeq - XM_006538850
RefSeq - NM_153423
RefSeq - XM_006538848
RefSeq - XM_006538849
RefSeq Peptide - NP_700472
swissprot - B1AUN0
swissprot - Q8BH43
Ensembl - ENSMUSG00000028868
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wasf2ENSDARG00000024209Danio rerio
 WASF2ENSGALG00000014012Gallus gallus
 WASF2ENSG00000158195Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wasf1 / Q8R5H6 / WAS protein family, member 1 / Q92558*ENSMUSG0000001983151
Wasf3 / Q8VHI6 / WAS protein family, member 3 / Q9UPY6*ENSMUSG0000002963648


Protein motifs (from Interpro)
Interpro ID Name
 IPR003124  WH2 domain
 IPR028288  SCAR/WAVE family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001667 ameboidal-type cell migration IMP
 biological_processGO:0006897 endocytosis IDA
 biological_processGO:0010592 positive regulation of lamellipodium assembly ISO
 biological_processGO:0016601 Rac protein signal transduction IMP
 biological_processGO:0030032 lamellipodium assembly IMP
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030048 actin filament-based movement IMP
 biological_processGO:0035855 megakaryocyte development IMP
 biological_processGO:0051497 negative regulation of stress fiber assembly ISO
 biological_processGO:0072673 lamellipodium morphogenesis IMP
 cellular_componentGO:0001726 ruffle IDA
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0031209 SCAR complex ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding ISO
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0051018 protein kinase A binding ISO


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000822 abnormal brain ventricle morphology "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Wasf2tm1Fwa/Wasf2tm1Fwa
Genetic Background: 129S/SvEv-Wasf2tm1Fwa

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Wasf2tm1Fwa/Wasf2tm1Fwa
Genetic Background: 129S/SvEv-Wasf2tm1Fwa

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Wasf2tm1Fwa/Wasf2tm1Fwa
Genetic Background: 129S/SvEv-Wasf2tm1Fwa

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003542 abnormal vascular endothelial cell development "malformation or aberrant differentiation of the cells that line the vasculature" [J:95387, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003974 abnormal endocardium morphology "malformation of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004784 abnormal anterior cardinal vein morphology "any structural anomaly of the two paired veins draining the cephalic part of the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Wasf2tm1Fwa/Wasf2tm1Fwa
Genetic Background: 129S/SvEv-Wasf2tm1Fwa

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Wasf2tm1Fwa/Wasf2tm1Fwa
Genetic Background: 129S/SvEv-Wasf2tm1Fwa

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0012253 abnormal intersomitic vessel morphology "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0012501 abnormal pericardial cavity morphology "any structural anomaly of the anatomical body cavity in which the heart lies; the pericardial cavity forms in the lateral plate mesoderm above the buccopharyngeal membrane, as part of the early intraembryonic coelom, and is initially continuous with the two early pleural cavities" [MGI:anna]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0020327 abnormal capillary branching pattern "any changes in the placement, morphology or number of divisions of the capillaries" [ORCID: orcid.org/0000-0003-4606-0597, PMID:14713950]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0020329 decreased capillary density "reduction in the number of capillaries in a given cross-sectional area of a tissue" [ORCID: orcid.org/0000-0003-4606-0597, PMID:20944627]
Show

Allelic Composition: MipGt(OST1231)Lex/Mip+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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