Manteia

ENSMUSG00000019977

Mus musculus

Features

Gene ID:	ENSMUSG00000019977

Biological name :	Hbs1l

Synonyms :	Hbs1l / HBS1-like protein / Q69ZS7

Possible biological names infered from orthology :	HBS1 like translational GTPase / Q9Y450

Species:	Mus musculus

Chr. number:	10
Strand:	1
Band:	A3
Gene start:	21295979
Gene end:	21368898

Corresponding Affymetrix probe sets:	10362036 (MoGene1.0st) 10363903 (MoGene1.0st) 1421029_a_at (Mouse Genome 430 2.0 Array) 1440050_at (Mouse Genome 430 2.0 Array) 1453604_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000020153 Ensembl peptide - ENSMUSP00000151421 Ensembl peptide - ENSMUSP00000151897 Ensembl peptide - ENSMUSP00000151689 Ensembl peptide - ENSMUSP00000090344 Ensembl peptide - ENSMUSP00000135902 NCBI entrez gene - 56422 See in Manteia. MGI - MGI:1891704 RefSeq - NM_019702 RefSeq - XM_006512805 RefSeq - XM_006512804 RefSeq - XM_006512803 RefSeq - NM_001042593 RefSeq - NM_001145209 RefSeq Peptide - NP_001036058 RefSeq Peptide - NP_001138681 RefSeq Peptide - NP_062676 swissprot - J3KMK0 swissprot - Q3TGM7 swissprot - Q69ZS7 swissprot - A0A1W2P6V8 swissprot - A0A1W2P833 swissprot - L7N209 Ensembl - ENSMUSG00000019977

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
hbs1l	ENSDARG00000036778	Danio rerio
HBS1L	ENSGALG00000013962	Gallus gallus
HBS1L	ENSG00000112339	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gspt2 / Q149F3 / G1 to S phase transition 2 / Q8IYD1*	ENSMUSG00000071723	30
Gspt1 / Q8R050 / G1 to S phase transition 1 / P15170*	ENSMUSG00000062203	30

Protein motifs (from Interpro)

Interpro ID	Name
IPR000795	Transcription factor, GTP-binding domain
IPR004160	Translation elongation factor EFTu/EF1A, C-terminal
IPR009000	Translation protein, beta-barrel domain superfamily
IPR009001	Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
IPR015033	HBS1-like protein, N-terminal
IPR027417	P-loop containing nucleoside triphosphate hydrolase
IPR037189	HBS1-like protein, N-terminal domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006412	translation	IBA
biological_process	GO:0006414	translational elongation	IEA
cellular_component	GO:0005622	intracellular	IBA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0003746	translation elongation factor activity	IEA
molecular_function	GO:0003924	GTPase activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005525	GTP binding	IEA

Pathways (from Reactome)

Pathway description

mRNA decay by 3 to 5 exoribonuclease

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000223	decreased monocyte count	"fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000443	abnormal snout morphology	"anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000445	short snout	"reduced length of the anterior facial part of the muzzle" [J:53370]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000480	increased number of ribs	"greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0001312	abnormal cornea morphology	"malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0001314	corneal opacity	"complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0002590	increased mean corpuscular volume	"greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0002599	increased mean platelet volume	"increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0003036	vertebral transformation	"homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0003049	abnormal lumbar vertebrae morphology	"malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0003795	abnormal bone structure		Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0003960	increased lean body mass	"more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005012	decreased eosinophil count	"fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005015	increased T cell number	"greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005103	abnormal retinal pigmentation	"anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005292	improved glucose tolerance	"better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005561	increased mean corpuscular hemoglobin	"greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005568	increased circulating total protein level	"greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008044	increased NK cell number	"greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008074	increased CD4-positive T cell number	"greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008346	increased gamma-delta T cell number	"greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008810	increased circulating iron level	"elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0010067	increased red blood cell distribution width	"higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0010168	increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	"a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0010844	increased effector memory CD4-positive, alpha-beta T cell number	"increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0010851	decreased effector memory CD8-positive, alpha-beta T cell number	"reduced number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0012764	increased alpha-beta T cell number	"greater number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013023	decreased Ly6C high monocyte number	"decrease in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [MGI:Annie_Speak]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013157	increased KLRG1+ CD4 alpha beta T cell number	"increase in the number of CD4+ alpha beta T cells that express KLRG1, a marker of effector/memory and regulatory T cells" [MGI:csmith]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013764	decreased T-helper cell number	"reduction in the number of an effector T cell that provides help in the form of secreted cytokines to other immune cells" [CL:0000912]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000033991	Ttc37 / tetratricopeptide repeat domain 37 / Q6PGP7*	/ complex
ENSMUSG00000040356	Skiv2l / superkiller viralicidic activity 2-like (S. cerevisiae) / Q15477* / Ski2 like RNA helicase*	/ complex
ENSMUSG00000061559	Wdr61 / Q9ERF3 / WD repeat domain 61 / Q9GZS3*	/ complex

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