ENSG00000112339


Homo sapiens

Features
Gene ID: ENSG00000112339
  
Biological name :HBS1L
  
Synonyms : HBS1L / HBS1 like translational GTPase / Q9Y450
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q23.3
Gene start: 134960378
Gene end: 135103056
  
Corresponding Affymetrix probe sets: 209314_s_at (Human Genome U133 Plus 2.0 Array)   209315_at (Human Genome U133 Plus 2.0 Array)   209316_s_at (Human Genome U133 Plus 2.0 Array)   240602_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000389826
Ensembl peptide - ENSP00000436620
Ensembl peptide - ENSP00000436472
Ensembl peptide - ENSP00000436256
Ensembl peptide - ENSP00000435608
Ensembl peptide - ENSP00000434855
Ensembl peptide - ENSP00000434533
Ensembl peptide - ENSP00000433161
Ensembl peptide - ENSP00000433030
Ensembl peptide - ENSP00000432092
Ensembl peptide - ENSP00000323566
Ensembl peptide - ENSP00000356794
Ensembl peptide - ENSP00000356796
Ensembl peptide - ENSP00000356800
Ensembl peptide - ENSP00000356811
NCBI entrez gene - 10767     See in Manteia.
OMIM - 612450
RefSeq - NM_001145207
RefSeq - NM_006620
RefSeq - NM_001145158
RefSeq - XM_017010192
RefSeq Peptide - NP_006611
RefSeq Peptide - NP_001138630
RefSeq Peptide - NP_001138679
swissprot - G5E991
swissprot - H0YD85
swissprot - E9PS53
swissprot - H0YES5
swissprot - J3QT46
swissprot - Q9Y450
swissprot - H0YDX7
swissprot - E9PN23
swissprot - E9PMN1
swissprot - E9PLR4
swissprot - E9PJ90
swissprot - E9PHZ9
swissprot - D9YZV0
swissprot - B7Z524
Ensembl - ENSG00000112339
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hbs1lENSDARG00000036778Danio rerio
 HBS1LENSGALG00000013962Gallus gallus
 Hbs1lENSMUSG00000019977Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GSPT2 / Q8IYD1 / G1 to S phase transition 2ENSG0000018936931
GSPT1 / P15170 / G1 to S phase transition 1ENSG0000010334231


Protein motifs (from Interpro)
Interpro ID Name
 IPR000795  Transcription factor, GTP-binding domain
 IPR004160  Translation elongation factor EFTu/EF1A, C-terminal
 IPR004161  Translation elongation factor EFTu-like, domain 2
 IPR009000  Translation protein, beta-barrel domain superfamily
 IPR009001  Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
 IPR015033  HBS1-like protein, N-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR037189  HBS1-like protein, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation TAS
 biological_processGO:0006414 translational elongation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003746 translation elongation factor activity IEA
 molecular_functionGO:0003924 GTPase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding TAS


Pathways (from Reactome)
Pathway description
mRNA decay by 3 to 5 exoribonuclease


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000204351 Q15477 / SKIV2L / Ski2 like RNA helicase  / complex
 ENSG00000198677 TTC37 / Q6PGP7 / tetratricopeptide repeat domain 37  / complex
 ENSG00000140395 WDR61 / Q9GZS3 / WD repeat domain 61  / complex






 

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