ENSG00000189369


Homo sapiens

Features
Gene ID: ENSG00000189369
  
Biological name :GSPT2
  
Synonyms : G1 to S phase transition 2 / GSPT2 / Q8IYD1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: p11.22
Gene start: 51743431
Gene end: 51746232
  
Corresponding Affymetrix probe sets: 205541_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000341247
NCBI entrez gene - 23708     See in Manteia.
OMIM - 300418
RefSeq - NM_018094
RefSeq Peptide - NP_060564
swissprot - Q8IYD1
Ensembl - ENSG00000189369
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gspt1ENSDARG00000031048Danio rerio
 gspt1lENSDARG00000098627Danio rerio
 GSPT1ENSGALG00000039500Gallus gallus
 Gspt2ENSMUSG00000071723Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GSPT1 / P15170 / G1 to S phase transition 1ENSG0000010334288
HBS1L / Q9Y450 / HBS1 like translational GTPaseENSG0000011233933


Protein motifs (from Interpro)
Interpro ID Name
 IPR000795  Transcription factor, GTP-binding domain
 IPR004160  Translation elongation factor EFTu/EF1A, C-terminal
 IPR004161  Translation elongation factor EFTu-like, domain 2
 IPR009000  Translation protein, beta-barrel domain superfamily
 IPR009001  Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
 IPR009818  Ataxin-2, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031157  Tr-type G domain, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0002184 cytoplasmic translational termination IBA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006415 translational termination TAS
 biological_processGO:0007049 cell cycle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0018444 translation release factor complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003747 translation release factor activity IBA
 molecular_functionGO:0003924 GTPase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000156239 N6AMT1 / Q9Y5N5 / N-6 adenine-specific DNA methyltransferase 1  / reaction
 ENSG00000173113 Q9UI30 / TRMT112 / tRNA methyltransferase subunit 11-2  / reaction
 ENSG00000120705 ETF1 / P62495 / eukaryotic translation termination factor 1  / complex






 

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