ENSG00000103342


Homo sapiens

Features
Gene ID: ENSG00000103342
  
Biological name :GSPT1
  
Synonyms : G1 to S phase transition 1 / GSPT1 / P15170
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p13.13
Gene start: 11868128
Gene end: 11916082
  
Corresponding Affymetrix probe sets: 201912_s_at (Human Genome U133 Plus 2.0 Array)   215438_x_at (Human Genome U133 Plus 2.0 Array)   217595_at (Human Genome U133 Plus 2.0 Array)   225276_at (Human Genome U133 Plus 2.0 Array)   234975_at (Human Genome U133 Plus 2.0 Array)   240452_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000456897
Ensembl peptide - ENSP00000399539
Ensembl peptide - ENSP00000398131
Ensembl peptide - ENSP00000454538
Ensembl peptide - ENSP00000456057
Ensembl peptide - ENSP00000408399
Ensembl peptide - ENSP00000454351
NCBI entrez gene - 2935     See in Manteia.
OMIM - 139259
RefSeq - NM_002094
RefSeq - NM_001130006
RefSeq - NM_001130007
RefSeq Peptide - NP_001123478
RefSeq Peptide - NP_002085
RefSeq Peptide - NP_001123479
swissprot - P15170
swissprot - H3BMT9
swissprot - H3BR35
swissprot - H3BSV8
Ensembl - ENSG00000103342
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gspt1ENSDARG00000031048Danio rerio
 gspt1lENSDARG00000098627Danio rerio
 GSPT1ENSGALG00000039500Gallus gallus
 Gspt1ENSMUSG00000062203Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GSPT2 / Q8IYD1 / G1 to S phase transition 2ENSG0000018936986
HBS1L / Q9Y450 / HBS1 like translational GTPaseENSG0000011233933


Protein motifs (from Interpro)
Interpro ID Name
 IPR000795  Transcription factor, GTP-binding domain
 IPR004160  Translation elongation factor EFTu/EF1A, C-terminal
 IPR004161  Translation elongation factor EFTu-like, domain 2
 IPR009000  Translation protein, beta-barrel domain superfamily
 IPR009001  Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
 IPR009818  Ataxin-2, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031157  Tr-type G domain, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0002184 cytoplasmic translational termination IBA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006415 translational termination TAS
 biological_processGO:0006479 protein methylation IDA
 cellular_componentGO:0005622 intracellular NAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0018444 translation release factor complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003747 translation release factor activity IMP
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000156239 N6AMT1 / Q9Y5N5 / N-6 adenine-specific DNA methyltransferase 1  / reaction
 ENSG00000173113 Q9UI30 / TRMT112 / tRNA methyltransferase subunit 11-2  / reaction
 ENSG00000120705 ETF1 / P62495 / eukaryotic translation termination factor 1  / complex






 

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