ENSG00000120705


Homo sapiens

Features
Gene ID: ENSG00000120705
  
Biological name :ETF1
  
Synonyms : ETF1 / eukaryotic translation termination factor 1 / P62495
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q31.2
Gene start: 138506095
Gene end: 138543300
  
Corresponding Affymetrix probe sets: 201573_s_at (Human Genome U133 Plus 2.0 Array)   201574_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000422203
Ensembl peptide - ENSP00000421288
Ensembl peptide - ENSP00000422272
Ensembl peptide - ENSP00000461082
Ensembl peptide - ENSP00000425689
Ensembl peptide - ENSP00000353741
NCBI entrez gene - 2107     See in Manteia.
OMIM - 600285
RefSeq - XM_017009222
RefSeq - NM_001256302
RefSeq - NM_001282185
RefSeq - NM_001291974
RefSeq - NM_001291975
RefSeq - NM_004730
RefSeq - XM_005271921
RefSeq - XM_017009221
RefSeq Peptide - NP_001243231
RefSeq Peptide - NP_001278903
RefSeq Peptide - NP_001278904
RefSeq Peptide - NP_004721
RefSeq Peptide - NP_001269114
swissprot - P62495
swissprot - D6RJE8
swissprot - D6RCB3
swissprot - I3L492
swissprot - B7Z7P8
Ensembl - ENSG00000120705
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 etf1aENSDARG00000105210Danio rerio
 etf1bENSDARG00000043976Danio rerio
 ETF1ENSGALG00000002262Gallus gallus
 Etf1ENSMUSG00000024360Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004403  Peptide chain release factor eRF1/aRF1
 IPR005140  eRF1 domain 1/Pelota-like
 IPR005141  eRF1 domain 2
 IPR005142  eRF1 domain 3
 IPR024049  Peptide Chain Release Factor eRF1/aRF1, N-terminal
 IPR029064  50S ribosomal protein L30e-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0006412 translation IEA
 biological_processGO:0006415 translational termination IEA
 biological_processGO:0006449 regulation of translational termination TAS
 biological_processGO:0006479 protein methylation IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003723 RNA binding TAS
 molecular_functionGO:0003747 translation release factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008079 translation termination factor activity TAS
 molecular_functionGO:0043022 ribosome binding TAS
 molecular_functionGO:1990825 sequence-specific mRNA binding IMP


Pathways (from Reactome)
Pathway description
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000156239 N6AMT1 / Q9Y5N5 / N-6 adenine-specific DNA methyltransferase 1  / reaction
 ENSG00000173113 Q9UI30 / TRMT112 / tRNA methyltransferase subunit 11-2  / reaction
 ENSG00000189369 GSPT2 / Q8IYD1 / G1 to S phase transition 2  / complex
 ENSG00000120705 ETF1 / P62495 / eukaryotic translation termination factor 1  / complex
 ENSG00000103342 GSPT1 / P15170 / G1 to S phase transition 1  / complex






 

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