ENSG00000140395


Homo sapiens

Features
Gene ID: ENSG00000140395
  
Biological name :WDR61
  
Synonyms : Q9GZS3 / WDR61 / WD repeat domain 61
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q25.1
Gene start: 78277835
Gene end: 78299794
  
Corresponding Affymetrix probe sets: 215156_at (Human Genome U133 Plus 2.0 Array)   221531_at (Human Genome U133 Plus 2.0 Array)   221532_s_at (Human Genome U133 Plus 2.0 Array)   232075_at (Human Genome U133 Plus 2.0 Array)   237208_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000455689
Ensembl peptide - ENSP00000453801
Ensembl peptide - ENSP00000453902
Ensembl peptide - ENSP00000267973
Ensembl peptide - ENSP00000453024
Ensembl peptide - ENSP00000453118
Ensembl peptide - ENSP00000453493
Ensembl peptide - ENSP00000453589
NCBI entrez gene - 80349     See in Manteia.
OMIM - 609540
RefSeq - XM_017022637
RefSeq - NM_001303247
RefSeq - NM_001303248
RefSeq - NM_025234
RefSeq - XM_011522094
RefSeq Peptide - NP_001290176
RefSeq Peptide - NP_001290177
RefSeq Peptide - NP_079510
swissprot - H0YLA1
swissprot - H0YM76
swissprot - H0YMF9
swissprot - H3BQA8
swissprot - H0YN81
swissprot - Q9GZS3
swissprot - H0YL19
Ensembl - ENSG00000140395
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wdr61ENSDARG00000007755Danio rerio
 WDR61ENSGALG00000003221Gallus gallus
 Wdr61ENSMUSG00000061559Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KATNB1 / Q9BVA0 / katanin regulatory subunit B1ENSG0000014085425
WDR38 / Q5JTN6 / WD repeat domain 38ENSG0000013691825
NLE1 / Q9NVX2 / notchless homolog 1ENSG0000007353623
WDR5B / Q86VZ2 / WD repeat domain 5BENSG0000019698122
POC1B / Q8TC44 / POC1 centriolar protein BENSG0000013932322
WDR5 / P61964 / WD repeat domain 5ENSG0000019636321
DAW1 / Q8N136 / dynein assembly factor with WD repeats 1ENSG0000012397721
POC1A / Q8NBT0 / POC1 centriolar protein AENSG0000016408721
P43034 / PAFAH1B1 / platelet activating factor acetylhydrolase 1b regulatory subunit 1ENSG0000000716819
Q96DI7 / SNRNP40 / small nuclear ribonucleoprotein U5 subunit 40ENSG0000006068817


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IDA
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051571 positive regulation of histone H3-K4 methylation IMP
 biological_processGO:0080182 histone H3-K4 trimethylation IMP
 biological_processGO:2001162 positive regulation of histone H3-K79 methylation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016593 Cdc73/Paf1 complex IDA
 cellular_componentGO:0035327 transcriptionally active chromatin IDA
 cellular_componentGO:0055087 Ski complex IDA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
mRNA decay by 3 to 5 exoribonuclease
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation
E3 ubiquitin ligases ubiquitinate target proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000140395 WDR61 / Q9GZS3 / WD repeat domain 61  / complex
 ENSG00000204351 Q15477 / SKIV2L / Ski2 like RNA helicase  / complex
 ENSG00000198677 TTC37 / Q6PGP7 / tetratricopeptide repeat domain 37  / complex
 ENSG00000112339 HBS1L / Q9Y450 / HBS1 like translational GTPase  / complex






 

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