ENSG00000196363


Homo sapiens

Features
Gene ID: ENSG00000196363
  
Biological name :WDR5
  
Synonyms : P61964 / WDR5 / WD repeat domain 5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q34.2
Gene start: 134135365
Gene end: 134159968
  
Corresponding Affymetrix probe sets: 223308_s_at (Human Genome U133 Plus 2.0 Array)   225170_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000351446
Ensembl peptide - ENSP00000477000
Ensembl peptide - ENSP00000477449
NCBI entrez gene - 11091     See in Manteia.
OMIM - 609012
RefSeq - XM_005272163
RefSeq - NM_017588
RefSeq - NM_052821
RefSeq Peptide - NP_438172
RefSeq Peptide - NP_060058
swissprot - P61964
swissprot - V9GYQ5
swissprot - V9GZ59
Ensembl - ENSG00000196363
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wdr5ENSDARG00000016903Danio rerio
 WDR5ENSGALG00000002659Gallus gallus
 Wdr5ENSMUSG00000026917Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WDR5B / Q86VZ2 / WD repeat domain 5BENSG0000019698185
NLE1 / Q9NVX2 / notchless homolog 1ENSG0000007353632
P43034 / PAFAH1B1 / platelet activating factor acetylhydrolase 1b regulatory subunit 1ENSG0000000716831
Q96DI7 / SNRNP40 / small nuclear ribonucleoprotein U5 subunit 40ENSG0000006068830
POC1B / Q8TC44 / POC1 centriolar protein BENSG0000013932328
POC1A / Q8NBT0 / POC1 centriolar protein AENSG0000016408728
DAW1 / Q8N136 / dynein assembly factor with WD repeats 1ENSG0000012397728
WDR38 / Q5JTN6 / WD repeat domain 38ENSG0000013691824
KATNB1 / Q9BVA0 / katanin regulatory subunit B1ENSG0000014085422
WDR61 / Q9GZS3 / WD repeat domain 61ENSG0000014039519


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0043966 histone H3 acetylation IDA
 biological_processGO:0043981 histone H4-K5 acetylation IDA
 biological_processGO:0043982 histone H4-K8 acetylation IDA
 biological_processGO:0043984 histone H4-K16 acetylation IDA
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0051568 histone H3-K4 methylation IEA
 biological_processGO:0060271 cilium assembly IBA
 cellular_componentGO:0000123 histone acetyltransferase complex IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IEA
 cellular_componentGO:0035097 histone methyltransferase complex IDA
 cellular_componentGO:0036064 ciliary basal body IBA
 cellular_componentGO:0044666 MLL3/4 complex IDA
 cellular_componentGO:0048188 Set1C/COMPASS complex IDA
 cellular_componentGO:0071339 MLL1 complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity TAS
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0042800 histone methyltransferase activity (H3-K4 specific) IDA
 molecular_functionGO:0043995 histone acetyltransferase activity (H4-K5 specific) IDA
 molecular_functionGO:0043996 histone acetyltransferase activity (H4-K8 specific) IDA
 molecular_functionGO:0046972 histone acetyltransferase activity (H4-K16 specific) IDA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines
HATs acetylate histones
RMTs methylate histone arginines
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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