ENSMUSG00000026917


Mus musculus

Features
Gene ID: ENSMUSG00000026917
  
Biological name :Wdr5
  
Synonyms : P61965 / Wdr5 / WD repeat domain 5
  
Possible biological names infered from orthology : P61964
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 27515157
Gene end: 27536535
  
Corresponding Affymetrix probe sets: 10470427 (MoGene1.0st)   1416581_at (Mouse Genome 430 2.0 Array)   1448389_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109585
Ensembl peptide - ENSMUSP00000121654
NCBI entrez gene - 140858     See in Manteia.
MGI - MGI:2155884
RefSeq - NM_080848
RefSeq - XM_006497672
RefSeq Peptide - NP_543124
swissprot - F6Q3W0
swissprot - P61965
Ensembl - ENSMUSG00000026917
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wdr5ENSDARG00000016903Danio rerio
 WDR5ENSGALG00000002659Gallus gallus
 WDR5ENSG00000196363Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wdr5b / Q9D7H2 / WD repeat domain 5B / Q86VZ2*ENSMUSG0000003437979
Nle1 / Q8VEJ4 / Notchless protein homolog 1 / Q9NVX2* / notchless homolog 1*ENSMUSG0000002069232
P63005 / Pafah1b1 / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 / P43034* / platelet activating factor acetylhydrolase 1b regulatory subunit 1*ENSMUSG0000002074531
Q6PE01 / Snrnp40 / U5 small nuclear ribonucleoprotein 40 kDa protein / Q96DI7* / small nuclear ribonucleoprotein U5 subunit 40*ENSMUSG0000007408830
Poc1a / Q8JZX3 / POC1 centriolar protein A / Q8NBT0*ENSMUSG0000002334528
Poc1b / Q8BHD1 / POC1 centriolar protein B / Q8TC44*ENSMUSG0000001995228
Katnb1 / Q8BG40 / Katanin p80 WD40 repeat-containing subunit B1 / Q9BVA0* / katanin regulatory subunit B1*ENSMUSG0000003178722
Wdr38 / Q9D994 / WD repeat domain 38 / Q5JTN6*ENSMUSG0000003529521
Wdr61 / Q9ERF3 / WD repeat domain 61 / Q9GZS3*ENSMUSG0000006155919
Daw1 / dynein assembly factor with WD repeats 1 / Q8N136*ENSMUSG0000005316117


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IDA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IGI
 biological_processGO:0043966 histone H3 acetylation IEA
 biological_processGO:0043981 histone H4-K5 acetylation IEA
 biological_processGO:0043982 histone H4-K8 acetylation IEA
 biological_processGO:0043984 histone H4-K16 acetylation IEA
 biological_processGO:0051568 histone H3-K4 methylation IEA
 biological_processGO:0060271 cilium assembly IBA
 cellular_componentGO:0000123 histone acetyltransferase complex IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IEA
 cellular_componentGO:0035097 histone methyltransferase complex IEA
 cellular_componentGO:0036064 ciliary basal body IBA
 cellular_componentGO:0044666 MLL3/4 complex IEA
 cellular_componentGO:0048188 Set1C/COMPASS complex IEA
 cellular_componentGO:0071339 MLL1 complex IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0042800 histone methyltransferase activity (H3-K4 specific) IEA
 molecular_functionGO:0043995 histone acetyltransferase activity (H4-K5 specific) IEA
 molecular_functionGO:0043996 histone acetyltransferase activity (H4-K8 specific) IEA
 molecular_functionGO:0046972 histone acetyltransferase activity (H4-K16 specific) IEA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines
HATs acetylate histones
RMTs methylate histone arginines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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