ENSMUSG00000053161


Mus musculus

Features
Gene ID: ENSMUSG00000053161
  
Biological name :Daw1
  
Synonyms : Daw1 / dynein assembly factor with WD repeats 1
  
Possible biological names infered from orthology : Q8N136
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C5
Gene start: 83159752
Gene end: 83210574
  
Corresponding Affymetrix probe sets: 10347895 (MoGene1.0st)   1454125_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000067102
Ensembl peptide - ENSMUSP00000117796
Ensembl peptide - ENSMUSP00000109063
Ensembl peptide - ENSMUSP00000067583
NCBI entrez gene - 71227     See in Manteia.
MGI - MGI:1923089
RefSeq - XM_011238711
RefSeq - XM_011238710
RefSeq - XM_006496547
RefSeq - NM_027725
RefSeq - XM_006496548
RefSeq - XM_006496549
RefSeq Peptide - NP_082001
swissprot - D6REG5
swissprot - A6H6T7
swissprot - D3YZQ8
swissprot - D3Z7A5
Ensembl - ENSMUSG00000053161
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 daw1ENSDARG00000021462Danio rerio
 DAW1ENSGALG00000002992Gallus gallus
 DAW1ENSG00000123977Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nle1 / Q8VEJ4 / Notchless protein homolog 1 / Q9NVX2* / notchless homolog 1*ENSMUSG0000002069227
P63005 / Pafah1b1 / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 / P43034* / platelet activating factor acetylhydrolase 1b regulatory subunit 1*ENSMUSG0000002074523
Poc1a / Q8JZX3 / POC1 centriolar protein A / Q8NBT0*ENSMUSG0000002334518
Wdr38 / Q9D994 / WD repeat domain 38 / Q5JTN6*ENSMUSG0000003529518
Q6PE01 / Snrnp40 / U5 small nuclear ribonucleoprotein 40 kDa protein / Q96DI7* / small nuclear ribonucleoprotein U5 subunit 40*ENSMUSG0000007408818
Wdr5 / P61965 / WD repeat domain 5 / P61964*ENSMUSG0000002691718
Katnb1 / Q8BG40 / Katanin p80 WD40 repeat-containing subunit B1 / Q9BVA0* / katanin regulatory subunit B1*ENSMUSG0000003178716
Poc1b / Q8BHD1 / POC1 centriolar protein B / Q8TC44*ENSMUSG0000001995216
Wdr5b / Q9D7H2 / WD repeat domain 5B / Q86VZ2*ENSMUSG0000003437915
Wdr61 / Q9ERF3 / WD repeat domain 61 / Q9GZS3*ENSMUSG0000006155913


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007507 heart development IMP
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
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Allelic Composition: Pcsk5b2b585Clo/Pcsk5b2b585Clo
Genetic Background: C57BL/6J-Pcsk5b2b585Clo

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0000644 dextrocardia "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pcsk5b2b585Clo/Pcsk5b2b585Clo
Genetic Background: C57BL/6J-Pcsk5b2b585Clo

Allelic Composition: Daw1b2b1584Clo/Daw1b2b1584Clo
Genetic Background: C57BL/6J-Daw1b2b1584Clo

 MP:0000690 absent spleen "missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Pcsk5b2b585Clo/Pcsk5b2b585Clo
Genetic Background: C57BL/6J-Pcsk5b2b585Clo

 MP:0002745 abnormal atrioventricular valve morphology "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0003178 left pulmonary isomerism "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]
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Allelic Composition: Pcsk5b2b585Clo/Pcsk5b2b585Clo
Genetic Background: C57BL/6J-Pcsk5b2b585Clo

Allelic Composition: Daw1b2b1584Clo/Daw1b2b1584Clo
Genetic Background: C57BL/6J-Daw1b2b1584Clo

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Daw1b2b1584Clo/Daw1b2b1584Clo
Genetic Background: C57BL/6J-Daw1b2b1584Clo

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pcsk5b2b585Clo/Pcsk5b2b585Clo
Genetic Background: C57BL/6J-Pcsk5b2b585Clo

Allelic Composition: Daw1b2b1584Clo/Daw1b2b1584Clo
Genetic Background: C57BL/6J-Daw1b2b1584Clo

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Daw1b2b1584Clo/Daw1b2b1584Clo
Genetic Background: C57BL/6J-Daw1b2b1584Clo

 MP:0006063 abnormal inferior vena cava morphology "structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Daw1b2b1584Clo/Daw1b2b1584Clo
Genetic Background: C57BL/6J-Daw1b2b1584Clo

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Pcsk5b2b585Clo/Pcsk5b2b585Clo
Genetic Background: C57BL/6J-Pcsk5b2b585Clo

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Pcsk5b2b585Clo/Pcsk5b2b585Clo
Genetic Background: C57BL/6J-Pcsk5b2b585Clo

 MP:0010808 right-sided stomach "stomach is present on the right side of the body instead of the left" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pcsk5b2b585Clo/Pcsk5b2b585Clo
Genetic Background: C57BL/6J-Pcsk5b2b585Clo

 MP:0011055 abnormal respiratory motile cilium physiology "any functional anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract; may include alterations in ciliary beating pattern or frequency" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcsk5b2b585Clo/Pcsk5b2b585Clo
Genetic Background: C57BL/6J-Pcsk5b2b585Clo

 MP:0011250 abdominal situs ambiguus "an abnormality in which the abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements" [MGI:csmith, PMID:18039396]
Show

Allelic Composition: Pcsk5b2b585Clo/Pcsk5b2b585Clo
Genetic Background: C57BL/6J-Pcsk5b2b585Clo

Allelic Composition: Daw1b2b1584Clo/Daw1b2b1584Clo
Genetic Background: C57BL/6J-Daw1b2b1584Clo

 MP:0011252 situs inversus totalis "the complete right to left reversal (transposition) of the thoracic and abdominal organs, including the heart (dextrocardia)" [MGI:csmith]
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Allelic Composition: Pcsk5b2b585Clo/Pcsk5b2b585Clo
Genetic Background: C57BL/6J-Pcsk5b2b585Clo

 MP:0011649 immotile respiratory cilia "failure of the multiple epithelial tiny, motile hair-like projections of the repiratory tract epithelium to beat with a characteristic whip-like pattern in order to promote transport of fluids and other cells across the epithelium of the respiratory tract" [MGI:csmith]
Show

Allelic Composition: Pcsk5b2b585Clo/Pcsk5b2b585Clo
Genetic Background: C57BL/6J-Pcsk5b2b585Clo

 MP:0011667 double outlet right ventricle with atrioventricular septal defect "a form of DORV in which there is also a complete atrioventricular canal" [MGI:csmith]
Show

Allelic Composition: Daw1b2b1584Clo/Daw1b2b1584Clo
Genetic Background: C57BL/6J-Daw1b2b1584Clo

 MP:0011683 dual inferior vena cava "presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein" [MGI:csmith, PMID:10835118]
Show

Allelic Composition: Pcsk5b2b585Clo/Pcsk5b2b585Clo
Genetic Background: C57BL/6J-Pcsk5b2b585Clo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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