ENSMUSG00000023345


Mus musculus

Features
Gene ID: ENSMUSG00000023345
  
Biological name :Poc1a
  
Synonyms : Poc1a / POC1 centriolar protein A / Q8JZX3
  
Possible biological names infered from orthology : Q8NBT0
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 106281061
Gene end: 106350521
  
Corresponding Affymetrix probe sets: 10588482 (MoGene1.0st)   1432202_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148880
Ensembl peptide - ENSMUSP00000150865
Ensembl peptide - ENSMUSP00000150549
Ensembl peptide - ENSMUSP00000149444
Ensembl peptide - ENSMUSP00000149273
Ensembl peptide - ENSMUSP00000149262
Ensembl peptide - ENSMUSP00000072064
Ensembl peptide - ENSMUSP00000140374
NCBI entrez gene - 70235     See in Manteia.
MGI - MGI:1917485
RefSeq - XM_006511831
RefSeq - NM_027354
RefSeq - XM_006511830
RefSeq Peptide - NP_081630
swissprot - A0A1L1SRG3
swissprot - A0A1L1SUQ2
swissprot - A0A1L1SQ32
swissprot - Q8JZX3
swissprot - A0A1L1SR15
swissprot - A0A1L1SR04
Ensembl - ENSMUSG00000023345
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 poc1aENSDARG00000078533Danio rerio
 POC1AENSGALG00000034572Gallus gallus
 POC1AENSG00000164087Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Poc1b / Q8BHD1 / POC1 centriolar protein B / Q8TC44*ENSMUSG0000001995257
Nle1 / Q8VEJ4 / Notchless protein homolog 1 / Q9NVX2* / notchless homolog 1*ENSMUSG0000002069224
Wdr5 / P61965 / WD repeat domain 5 / P61964*ENSMUSG0000002691723
Katnb1 / Q8BG40 / Katanin p80 WD40 repeat-containing subunit B1 / Q9BVA0* / katanin regulatory subunit B1*ENSMUSG0000003178723
P63005 / Pafah1b1 / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 / P43034* / platelet activating factor acetylhydrolase 1b regulatory subunit 1*ENSMUSG0000002074523
Q6PE01 / Snrnp40 / U5 small nuclear ribonucleoprotein 40 kDa protein / Q96DI7* / small nuclear ribonucleoprotein U5 subunit 40*ENSMUSG0000007408821
Wdr5b / Q9D7H2 / WD repeat domain 5B / Q86VZ2*ENSMUSG0000003437920
Wdr38 / Q9D994 / WD repeat domain 38 / Q5JTN6*ENSMUSG0000003529520
Wdr61 / Q9ERF3 / WD repeat domain 61 / Q9GZS3*ENSMUSG0000006155915
Daw1 / dynein assembly factor with WD repeats 1 / Q8N136*ENSMUSG0000005316114


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003431 growth plate cartilage chondrocyte development IMP
 biological_processGO:0007052 mitotic spindle organization IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0010825 positive regulation of centrosome duplication IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0060348 bone development IMP
 biological_processGO:1905515 non-motile cilium assembly IMP
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005814 centriole ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0036064 ciliary basal body ISO
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001116 small gonad "reduced size of the testis or the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Poc1acha/Poc1acha
Genetic Background: involves: DBA/2J * M. m. castaneus

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Poc1acha/Poc1acha
Genetic Background: involves: DBA/2J * M. m. castaneus

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0004708 short lumbar vertebrae "reduced length of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Poc1acha/Poc1acha
Genetic Background: involves: DBA/2J * M. m. castaneus

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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