ENSG00000073536


Homo sapiens

Features
Gene ID: ENSG00000073536
  
Biological name :NLE1
  
Synonyms : NLE1 / notchless homolog 1 / Q9NVX2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q12
Gene start: 35128753
Gene end: 35142315
  
Corresponding Affymetrix probe sets: 203866_at (Human Genome U133 Plus 2.0 Array)   203867_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000413572
Ensembl peptide - ENSP00000466764
Ensembl peptide - ENSP00000354075
Ensembl peptide - ENSP00000468339
Ensembl peptide - ENSP00000465420
Ensembl peptide - ENSP00000466588
NCBI entrez gene - 54475     See in Manteia.
RefSeq - XM_017024777
RefSeq - NM_001014445
RefSeq - NM_018096
RefSeq Peptide - NP_001014445
RefSeq Peptide - NP_060566
swissprot - A0A0A0MRH0
swissprot - K7ERN7
swissprot - K7EN33
swissprot - K7EK23
swissprot - Q9NVX2
Ensembl - ENSG00000073536
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nle1ENSDARG00000057105Danio rerio
 ENSGALG00000004691Gallus gallus
 ENSGALG00000036963Gallus gallus
 Nle1ENSMUSG00000020692Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DAW1 / Q8N136 / dynein assembly factor with WD repeats 1ENSG0000012397724
P43034 / PAFAH1B1 / platelet activating factor acetylhydrolase 1b regulatory subunit 1ENSG0000000716822
WDR5 / P61964 / WD repeat domain 5ENSG0000019636322
WDR5B / Q86VZ2 / WD repeat domain 5BENSG0000019698121
WDR38 / Q5JTN6 / WD repeat domain 38ENSG0000013691820
POC1A / Q8NBT0 / POC1 centriolar protein AENSG0000016408720
POC1B / Q8TC44 / POC1 centriolar protein BENSG0000013932320
KATNB1 / Q9BVA0 / katanin regulatory subunit B1ENSG0000014085418
Q96DI7 / SNRNP40 / small nuclear ribonucleoprotein U5 subunit 40ENSG0000006068818
WDR61 / Q9GZS3 / WD repeat domain 61ENSG0000014039514


Protein motifs (from Interpro)
Interpro ID Name
 IPR001632  G-protein, beta subunit
 IPR001680  WD40 repeat
 IPR012972  NLE
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000027 ribosomal large subunit assembly IBA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001826 inner cell mass cell differentiation IEA
 biological_processGO:0007219 Notch signaling pathway IBA
 biological_processGO:0042273 ribosomal large subunit biogenesis IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IEA
 biological_processGO:0048705 skeletal system morphogenesis IEA
 biological_processGO:0061484 hematopoietic stem cell homeostasis IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005840 ribosome IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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