| MP:0000358 | abnormal cell content/ morphology | "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Apctm2Rfo/Apc+,Smad4E6sad/Smad4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0000774 | reduced brain size | "smaller appearance of the brain" [J:35802] |
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0000851 | cerebellum hypoplasia | "reduced cell number in the cerebellum" [MGI:CLS, J:45302] |
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0000864 | abnormal vermis | "malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509] |
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0000886 | abnormal cerebellar granule layer | "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg
Genetic Background: involves: 129 * C57BL/6 * FVB/N
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| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Kdrtm1.1Jamb/Kdrtm1.1Jamb,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR
Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0001392 | abnormal locomotor activity | "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0001859 | kidney inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Kdrtm1.1Jamb/Kdrtm1.1Jamb,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kdrtm1.1Jamb/Kdrtm1.1Jamb,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR
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| MP:0002135 | abnormal kidney morphology | "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kdrtm1.1Jamb/Kdrtm1.1Jamb,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR
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| MP:0002136 | abnormal kidney physiology | "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kdrtm1.1Jamb/Kdrtm1.1Jamb,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR
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| MP:0002573 | behavioral despair | "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395] |
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Allelic Composition: Gjb6tm1Kwi/Gjb6tm1Kwi
Genetic Background: involves: 129P2/OlaHsd
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| MP:0002703 | abnormal renal tubules | "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Kdrtm1.1Jamb/Kdrtm1.1Jamb,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR
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| MP:0002705 | dilated renal tubules | "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Kdrtm1.1Jamb/Kdrtm1.1Jamb,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR
Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0002989 | small kidney | "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kdrtm1.1Jamb/Kdrtm1.1Jamb,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR
Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0003313 | abnormal locomotor activation | "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0003675 | kidney cysts | "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Kdrtm1.1Jamb/Kdrtm1.1Jamb,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR
Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0003985 | renal fibrosis | "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0004021 | abnormal rod electrophysiology | "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Smad1tm2Rob/Smad1tm2Sor
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
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| MP:0004272 | abnormal basement membrane morphology | "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220] |
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0005164 | abnormal response to injury | "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0005419 | hypoalbuminemia | "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0005553 | increased circulating creatinine level | "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Kdrtm1.1Jamb/Kdrtm1.1Jamb,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR
Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0006072 | abnormal retinal apoptosis | "increase or decrease in the number of cells in the retina undergoing programmed cell death" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:] |
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg
Genetic Background: involves: 129 * C57BL/6 * FVB/N
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| MP:0008450 | retinal photoreceptor degeneration | "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Rhotm1Jlem/Rho+
Genetic Background: involves: 129 * C57BL/6 * FVB/N
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| MP:0008489 | postnatal slow weight gain | "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
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| MP:0008515 | thin retinal outer nuclear layer | "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Smad1tm2Rob/Smad1tm2Sor
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
Allelic Composition: Ahi1tm1Jgg/Ahi1tm2.1Jgg,Nphp1tm1Jgg/Nphp1+,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI
Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Ahi1tm1Jgg/Ahi1+,Nphp1tm1Jgg/Nphp1tm1Jgg
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI
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| MP:0008585 | absent photoreceptor outer segment | "absence of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Rhotm1Jlem/Rho+
Genetic Background: involves: 129 * C57BL/6 * FVB/N
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| MP:0009719 | reduced cerebellar foliation | "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0009959 | abnormal cerebellar hemisphere morphology | "any structural anomaly of the paired regions of the cerebellum that lie outside and lateral to the central vermis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg
Genetic Background: involves: 129 * C57BL/6 * FVB/N
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0013305 | isosthenuria | "inability of the kidneys to produce either a concentrated or a dilute urine; refers to a state in chronic renal disease in which the kidney cannot form urine with a higher or a lower specific gravity (concentration) than that of protein-free plasma; the specific gravity of the urine becomes fixed, irrespective of the fluid intake" [MGI:Anna] |
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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