ENSMUSG00000019987


Mus musculus

Features
Gene ID: ENSMUSG00000019987
  
Biological name :Arg1
  
Synonyms : Arg1 / Arginase-1 / Q61176
  
Possible biological names infered from orthology : P05089
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A4
Gene start: 24915221
Gene end: 24927484
  
Corresponding Affymetrix probe sets: 10368343 (MoGene1.0st)   1419549_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020161
NCBI entrez gene - 11846     See in Manteia.
MGI - MGI:88070
RefSeq - NM_007482
RefSeq Peptide - NP_031508
swissprot - Q61176
Ensembl - ENSMUSG00000019987
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arg1ENSDARG00000057429Danio rerio
 ARG1ENSG00000118520Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arg2 / O08691 / Arginase-2, mitochondrial / P78540* / arginase 2*ENSMUSG0000002112559
Agmat / A2AS89 / Agmatinase, mitochondrial / Q9BSE5* / agmatinase*ENSMUSG0000004070620


Protein motifs (from Interpro)
Interpro ID Name
 IPR006035  Ureohydrolase
 IPR014033  Arginase
 IPR020855  Ureohydrolase, manganese-binding site
 IPR023696  Ureohydrolase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000050 urea cycle IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006525 arginine metabolic process IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009635 response to herbicide IEA
 biological_processGO:0010042 response to manganese ion IEA
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0010269 response to selenium ion IEA
 biological_processGO:0010963 regulation of L-arginine import IEA
 biological_processGO:0014075 response to amine IEA
 biological_processGO:0019547 arginine catabolic process to ornithine IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032964 collagen biosynthetic process IEA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0033197 response to vitamin E IEA
 biological_processGO:0042130 negative regulation of T cell proliferation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042832 defense response to protozoan IMP
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046007 negative regulation of activated T cell proliferation IMP
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0051597 response to methylmercury IEA
 biological_processGO:0060056 mammary gland involution IEA
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0060336 negative regulation of interferon-gamma-mediated signaling pathway IEA
 biological_processGO:0070207 protein homotrimerization IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070965 positive regulation of neutrophil mediated killing of fungus IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071353 cellular response to interleukin-4 IEA
 biological_processGO:0071377 cellular response to glucagon stimulus IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:2000552 negative regulation of T-helper 2 cell cytokine production IMP
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0004053 arginase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Urea cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: F3tm1Dco/F3tm1Dco,Tg(F3)1Nmk/?
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002138 abnormal liver/biliary system morphology "structural abnormality or aberrant development of any of the tissues of the liver or biliary system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prss8fr/Prss8tm1.1Hum
Genetic Background: involves: 129/Sv * FS/EiJ

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arg1tm1Pmu/Arg1tm1Pmu,Lyz2tm1(cre)Ifo/?
Genetic Background: B6.Cg-Arg1tm1Pmu Lyz2tm1(cre)Ifo

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arg1tm1Pmu/Arg1tm1Pmu,Lyz2tm1(cre)Ifo/?
Genetic Background: B6.Cg-Arg1tm1Pmu Lyz2tm1(cre)Ifo

Allelic Composition: Arg1tm1Ekoe/Arg1tm1Ekoe
Genetic Background: involves: 129P2/OlaHsd

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Prss8fr/Prss8tm1.1Hum
Genetic Background: involves: 129/Sv * FS/EiJ

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arg1tm1Pmu/Arg1tm1Pmu,Lyz2tm1(cre)Ifo/?
Genetic Background: B6.Cg-Arg1tm1Pmu Lyz2tm1(cre)Ifo

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arg1tm1Pmu/Arg1tm1Pmu,Lyz2tm1(cre)Ifo/?
Genetic Background: B6.Cg-Arg1tm1Pmu Lyz2tm1(cre)Ifo

 MP:0005309 increased circulating ammonia level "significantly elevated levels of ammonia or its compounds in blood; often associated with liver failure and hepatic encephalopathy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83263]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arg1tm1Ekoe/Arg1tm1Ekoe
Genetic Background: involves: 129P2/OlaHsd

 MP:0011076 increased macrophage nitric oxide production "greater production of macrophage-derived nitric oxide due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F3tm1Dco/F3tm1Dco,Tg(F3)1Nmk/?
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Arg1tm1Pmu/Arg1tm1Pmu,Tg(Tek-cre)1Ywa/?
Genetic Background: B6.Cg-Arg1tm1Pmu Tg(Tek-cre)1Ywa

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019987 Arg1 / Q61176 / Arginase-1 / P05089*  / complex






 

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