ENSMUSG00000021125


Mus musculus

Features
Gene ID: ENSMUSG00000021125
  
Biological name :Arg2
  
Synonyms : Arg2 / Arginase-2, mitochondrial / O08691
  
Possible biological names infered from orthology : arginase 2 / P78540
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C3
Gene start: 79130777
Gene end: 79156301
  
Corresponding Affymetrix probe sets: 10396831 (MoGene1.0st)   1418847_at (Mouse Genome 430 2.0 Array)   1438841_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021550
NCBI entrez gene - 11847     See in Manteia.
MGI - MGI:1330806
RefSeq - NM_009705
RefSeq Peptide - NP_033835
swissprot - O08691
Ensembl - ENSMUSG00000021125
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arg2ENSDARG00000039269Danio rerio
 ARG2ENSGALG00000009519Gallus gallus
 ARG2ENSG00000081181Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arg1 / Q61176 / Arginase-1 / P05089*ENSMUSG0000001998753
Agmat / A2AS89 / Agmatinase, mitochondrial / Q9BSE5* / agmatinase*ENSMUSG0000004070620


Protein motifs (from Interpro)
Interpro ID Name
 IPR006035  Ureohydrolase
 IPR014033  Arginase
 IPR020855  Ureohydrolase, manganese-binding site
 IPR023696  Ureohydrolase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000050 urea cycle IEA
 biological_processGO:0001657 ureteric bud development IEP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002829 negative regulation of type 2 immune response IMP
 biological_processGO:0006525 arginine metabolic process IEA
 biological_processGO:0006941 striated muscle contraction IMP
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050706 regulation of interleukin-1 beta secretion IMP
 biological_processGO:0071641 negative regulation of macrophage inflammatory protein 1 alpha production IMP
 biological_processGO:0071644 negative regulation of chemokine (C-C motif) ligand 4 production IMP
 biological_processGO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production IMP
 biological_processGO:1900425 negative regulation of defense response to bacterium IMP
 biological_processGO:1903426 regulation of reactive oxygen species biosynthetic process IMP
 biological_processGO:1904468 negative regulation of tumor necrosis factor secretion IMP
 biological_processGO:1905077 negative regulation of interleukin-17 secretion IMP
 biological_processGO:1905403 negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process IMP
 biological_processGO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
 biological_processGO:2000666 negative regulation of interleukin-13 secretion IMP
 biological_processGO:2000774 positive regulation of cellular senescence IEA
 cellular_componentGO:0005739 mitochondrion ISO
 molecular_functionGO:0004053 arginase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Urea cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Hephsla/Y,Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Arg2tm1Weo/Arg2+
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021125 Arg2 / O08691 / Arginase-2, mitochondrial / P78540* / arginase 2*  / complex






 

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