ENSG00000081181


Homo sapiens

Features
Gene ID: ENSG00000081181
  
Biological name :ARG2
  
Synonyms : ARG2 / arginase 2 / P78540
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q24.1
Gene start: 67619798
Gene end: 67651720
  
Corresponding Affymetrix probe sets: 203945_at (Human Genome U133 Plus 2.0 Array)   203946_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000261783
NCBI entrez gene - 384     See in Manteia.
OMIM - 107830
RefSeq - NM_001172
RefSeq Peptide - NP_001163
swissprot - A0A024R6A0
swissprot - P78540
Ensembl - ENSG00000081181
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arg2ENSDARG00000039269Danio rerio
 ARG2ENSGALG00000009519Gallus gallus
 Arg2ENSMUSG00000021125Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARG1 / P05089 / arginase 1ENSG0000011852054
AGMAT / Q9BSE5 / agmatinaseENSG0000011677123


Protein motifs (from Interpro)
Interpro ID Name
 IPR006035  Ureohydrolase
 IPR014033  Arginase
 IPR020855  Ureohydrolase, manganese-binding site
 IPR023696  Ureohydrolase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000050 urea cycle TAS
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002829 negative regulation of type 2 immune response IEA
 biological_processGO:0006525 arginine metabolic process IEA
 biological_processGO:0006809 nitric oxide biosynthetic process TAS
 biological_processGO:0006941 striated muscle contraction IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050706 regulation of interleukin-1 beta secretion IEA
 biological_processGO:0071641 negative regulation of macrophage inflammatory protein 1 alpha production IEA
 biological_processGO:0071644 negative regulation of chemokine (C-C motif) ligand 4 production IEA
 biological_processGO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production IEA
 biological_processGO:1900425 negative regulation of defense response to bacterium IEA
 biological_processGO:1903426 regulation of reactive oxygen species biosynthetic process IEA
 biological_processGO:1904468 negative regulation of tumor necrosis factor secretion IEA
 biological_processGO:1905077 negative regulation of interleukin-17 secretion IEA
 biological_processGO:1905403 negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process IEA
 biological_processGO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation IEA
 biological_processGO:2000666 negative regulation of interleukin-13 secretion IEA
 biological_processGO:2000774 positive regulation of cellular senescence IDA
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005759 mitochondrial matrix TAS
 molecular_functionGO:0004053 arginase activity IMP
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Urea cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000081181 ARG2 / P78540 / arginase 2  / complex






 

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