ENSMUSG00000020307


Mus musculus

Features
Gene ID: ENSMUSG00000020307
  
Biological name :Cdc34
  
Synonyms : Cdc34 / cell division cycle 34 / Q8CFI2
  
Possible biological names infered from orthology : P49427
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 79682195
Gene end: 79688398
  
Corresponding Affymetrix probe sets: 10364455 (MoGene1.0st)   1434879_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128806
Ensembl peptide - ENSMUSP00000152000
Ensembl peptide - ENSMUSP00000151998
Ensembl peptide - ENSMUSP00000151880
Ensembl peptide - ENSMUSP00000151798
Ensembl peptide - ENSMUSP00000151790
Ensembl peptide - ENSMUSP00000151763
Ensembl peptide - ENSMUSP00000020550
NCBI entrez gene - 216150     See in Manteia.
MGI - MGI:102657
RefSeq - XM_017313888
RefSeq - NM_177613
RefSeq - XM_006513482
RefSeq - XM_006513483
RefSeq - XM_017313887
RefSeq Peptide - NP_808281
swissprot - A0A1W2P8B1
swissprot - Q8CFI2
swissprot - A0A1W2P861
swissprot - A0A1W2P7U9
swissprot - A0A1W2P7U1
swissprot - A0A1W2P892
swissprot - A0A1W2P7T2
Ensembl - ENSMUSG00000020307
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc34aENSDARG00000069708Danio rerio
 cdc34bENSDARG00000012627Danio rerio
 CDC34ENSGALG00000024332Gallus gallus
 CDC34ENSG00000099804Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdc34b / cell division cycle 34B / CDC34* / P49427* / cell division cycle 34*ENSMUSG0000002087091
Q6ZWZ2 / Ube2r2 / ubiquitin-conjugating enzyme E2R 2 / Q712K3*ENSMUSG0000003624180
P62254 / Ube2g1 / ubiquitin-conjugating enzyme E2G 1 / P62253*ENSMUSG0000002079436
P60605 / Ube2g2 / ubiquitin-conjugating enzyme E2G 2 / P60604*ENSMUSG0000000929332


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination ISO
 biological_processGO:0006513 protein monoubiquitination ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0035458 cellular response to interferon-beta ISO
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling ISO
 biological_processGO:0070936 protein K48-linked ubiquitination ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016607 nuclear speck ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IBA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity ISO


Pathways (from Reactome)
Pathway description
Downstream TCR signaling
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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