ENSMUSG00000020794


Mus musculus

Features
Gene ID: ENSMUSG00000020794
  
Biological name :Ube2g1
  
Synonyms : P62254 / Ube2g1 / ubiquitin-conjugating enzyme E2G 1
  
Possible biological names infered from orthology : P62253
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B4
Gene start: 72607283
Gene end: 72686481
  
Corresponding Affymetrix probe sets: 10378114 (MoGene1.0st)   10338111 (MoGene1.0st)   10338384 (MoGene1.0st)   10338514 (MoGene1.0st)   10338540 (MoGene1.0st)   10338712 (MoGene1.0st)   10340013 (MoGene1.0st)   10340420 (MoGene1.0st)   10340937 (MoGene1.0st)   10340991 (MoGene1.0st)   10341369 (MoGene1.0st)   10339969 (MoGene1.0st)   10340253 (MoGene1.0st)   10342070 (MoGene1.0st)   1415688_at (Mouse Genome 430 2.0 Array)   1455094_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117588
Ensembl peptide - ENSMUSP00000021148
NCBI entrez gene - 67128     See in Manteia.
MGI - MGI:1914378
RefSeq - NM_025985
RefSeq Peptide - NP_080261
swissprot - D6RES1
swissprot - P62254
swissprot - Q5F239
Ensembl - ENSMUSG00000020794
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ube2g1aENSDARG00000015292Danio rerio
 UBE2G1ENSGALG00000001441Gallus gallus
 P62253ENSG00000132388Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6ZWZ2 / Ube2r2 / ubiquitin-conjugating enzyme E2R 2 / Q712K3*ENSMUSG0000003624151
Cdc34b / cell division cycle 34B / CDC34* / P49427* / cell division cycle 34*ENSMUSG0000002087049
Cdc34 / Q8CFI2 / cell division cycle 34 / P49427*ENSMUSG0000002030749
P60605 / Ube2g2 / ubiquitin-conjugating enzyme E2G 2 / P60604*ENSMUSG0000000929347


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0044257 cellular protein catabolic process IEA
 biological_processGO:0070534 protein K63-linked ubiquitination IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0005385 cardiovascular system phenotype 
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0010851 decreased effector memory CD8-positive, alpha-beta T cell number "reduced number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0013648 increased CD11b-high dendritic cell number "increase in the number of dendritic cells expressing high levels of CD11b which usually depend on Irf4 for their development" [MGI:Saran, PMID:23516985]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0013675 decreased Ly6C-positive mature NK cell number "reduction in the number of mature NK cells expressing the memory marker Ly6C" [MGI:Saran]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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