ENSG00000099804


Homo sapiens

Features
Gene ID: ENSG00000099804
  
Biological name :CDC34
  
Synonyms : CDC34 / cell division cycle 34 / P49427
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 531712
Gene end: 542092
  
Corresponding Affymetrix probe sets: 212540_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000476107
Ensembl peptide - ENSP00000215574
Ensembl peptide - ENSP00000475282
Ensembl peptide - ENSP00000475610
NCBI entrez gene - 997     See in Manteia.
OMIM - 116948
RefSeq - XM_006722952
RefSeq - NM_004359
RefSeq - XM_005259690
RefSeq Peptide - NP_004350
swissprot - P49427
swissprot - U3KPV8
swissprot - U3KQ77
swissprot - U3KQP9
swissprot - A0A024R1Z1
Ensembl - ENSG00000099804
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc34aENSDARG00000069708Danio rerio
 cdc34bENSDARG00000012627Danio rerio
 CDC34ENSGALG00000024332Gallus gallus
 Cdc34ENSMUSG00000020307Mus musculus
 Cdc34bENSMUSG00000020870Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q712K3 / UBE2R2 / ubiquitin conjugating enzyme E2 R2ENSG0000010734180
P62253 / UBE2G1 / ubiquitin conjugating enzyme E2 G1ENSG0000013238836
P60604 / UBE2G2 / ubiquitin conjugating enzyme E2 G2ENSG0000018478732


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle NAS
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0006270 DNA replication initiation NAS
 biological_processGO:0006464 cellular protein modification process NAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0035458 cellular response to interferon-beta IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0070848 response to growth factor IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 biological_processGO:0090261 positive regulation of inclusion body assembly IEA
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IBA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity IDA


Pathways (from Reactome)
Pathway description
Downstream TCR signaling
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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