ENSMUSG00000020402


Mus musculus

Features
Gene ID: ENSMUSG00000020402
  
Biological name :Vdac1
  
Synonyms : Q60932 / Vdac1 / voltage-dependent anion channel 1
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 52360860
Gene end: 52389397
  
Corresponding Affymetrix probe sets: 10375941 (MoGene1.0st)   1415998_at (Mouse Genome 430 2.0 Array)   1436992_x_at (Mouse Genome 430 2.0 Array)   1437192_x_at (Mouse Genome 430 2.0 Array)   1437452_x_at (Mouse Genome 430 2.0 Array)   1437947_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020673
Ensembl peptide - ENSMUSP00000099819
Ensembl peptide - ENSMUSP00000116919
NCBI entrez gene - 22333     See in Manteia.
MGI - MGI:106919
RefSeq - NM_011694
RefSeq - XM_017314500
RefSeq Peptide - NP_035824
swissprot - F2Z471
swissprot - Q60932
Ensembl - ENSMUSG00000020402
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vdac1ENSDARG00000045132Danio rerio
 VDAC1ENSGALG00000006503Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vdac2 / Q60930 / voltage-dependent anion channel 2 / P45880*ENSMUSG0000002177174
Vdac3 / Q60931 / voltage-dependent anion channel 3 / Q9Y277*ENSMUSG0000000889267


Protein motifs (from Interpro)
Interpro ID Name
 IPR001925  Porin, eukaryotic type
 IPR027246  Eukaryotic porin/Tom40
 IPR030270  Voltage-dependent anion-selective channel protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006820 anion transport ISO
 biological_processGO:0006851 mitochondrial calcium ion transmembrane transport IEA
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0007270 neuron-neuron synaptic transmission IMP
 biological_processGO:0007612 learning IMP
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0098656 anion transmembrane transport IEA
 biological_processGO:1903146 regulation of autophagy of mitochondrion IMP
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane ISS
 cellular_componentGO:0005743 mitochondrial inner membrane ISS
 cellular_componentGO:0005757 mitochondrial permeability transition pore complex ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042645 mitochondrial nucleoid ISO
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0046930 pore complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005253 anion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008308 voltage-gated anion channel activity IDA
 molecular_functionGO:0015288 porin activity IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0044325 ion channel binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc,Vdac3tm1Wjc/Vdac3tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc,Vdac3tm1Wjc/Vdac3tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc,Vdac3tm1Wjc/Vdac3tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc,Vdac3tm1Wjc/Vdac3tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc,Vdac3tm1Wjc/Vdac3tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002920 reduced paired-pulse facilitation "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc,Vdac3tm1Wjc/Vdac3tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc,Vdac3tm1Wjc/Vdac3tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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