ENSMUSG00000021771


Mus musculus

Features
Gene ID: ENSMUSG00000021771
  
Biological name :Vdac2
  
Synonyms : Q60930 / Vdac2 / voltage-dependent anion channel 2
  
Possible biological names infered from orthology : P45880
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: A3
Gene start: 21825238
Gene end: 21845879
  
Corresponding Affymetrix probe sets: 10413138 (MoGene1.0st)   10531286 (MoGene1.0st)   1415990_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123032
Ensembl peptide - ENSMUSP00000152916
Ensembl peptide - ENSMUSP00000134023
Ensembl peptide - ENSMUSP00000133525
Ensembl peptide - ENSMUSP00000022293
Ensembl peptide - ENSMUSP00000115560
NCBI entrez gene - 22334     See in Manteia.
MGI - MGI:106915
RefSeq - NM_011695
RefSeq Peptide - NP_035825
swissprot - G3UX26
swissprot - D3YZT5
swissprot - Q60930
swissprot - D3YUN8
swissprot - A0A286YCR8
Ensembl - ENSMUSG00000021771
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vdac2ENSDARG00000013623Danio rerio
 VDAC2ENSGALG00000005002Gallus gallus
 VDAC2ENSG00000165637Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vdac1 / Q60932 / voltage-dependent anion channel 1ENSMUSG0000002040271
Vdac3 / Q60931 / voltage-dependent anion channel 3 / Q9Y277*ENSMUSG0000000889270


Protein motifs (from Interpro)
Interpro ID Name
 IPR001925  Porin, eukaryotic type
 IPR027246  Eukaryotic porin/Tom40
 IPR030277  Voltage-dependent anion-selective channel protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006820 anion transport IEA
 biological_processGO:0007339 binding of sperm to zona pellucida IEA
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0032272 negative regulation of protein polymerization IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0098656 anion transmembrane transport IEA
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0046930 pore complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008308 voltage-gated anion channel activity IEA
 molecular_functionGO:0015288 porin activity IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Snx10tm1c(EUCOMM)Raba/Snx10tm1c(EUCOMM)Raba
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc,Baxtm2Sjk/Baxtm2Sjk,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Snx10tm1c(EUCOMM)Raba/Snx10tm1c(EUCOMM)Raba
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc,Baxtm2Sjk/Baxtm2Sjk,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009258 abnormal thymocyte apoptosis "change in the timing or the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893]
Show

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Snx10tm1c(EUCOMM)Raba/Snx10tm1c(EUCOMM)Raba
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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