ENSMUSG00000020435


Mus musculus

Features
Gene ID: ENSMUSG00000020435
  
Biological name :Osbp2
  
Synonyms : Osbp2 / Oxysterol-binding protein 2 / Q5QNQ6
  
Possible biological names infered from orthology : Q969R2
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 3703731
Gene end: 3863903
  
Corresponding Affymetrix probe sets: 10383767 (MoGene1.0st)   1428355_at (Mouse Genome 430 2.0 Array)   1428356_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116490
Ensembl peptide - ENSMUSP00000099156
Ensembl peptide - ENSMUSP00000100015
Ensembl peptide - ENSMUSP00000068652
Ensembl peptide - ENSMUSP00000116361
NCBI entrez gene - 74309     See in Manteia.
MGI - MGI:1921559
RefSeq - XM_017314810
RefSeq - NM_001302630
RefSeq - NM_001302631
RefSeq - NM_152818
RefSeq - XM_011243766
RefSeq - XM_011243767
RefSeq - XM_011243768
RefSeq - XM_011243769
RefSeq - XM_011243770
RefSeq - XM_011243771
RefSeq - XM_017314808
RefSeq - XM_017314809
RefSeq - XM_006514849
RefSeq - XM_006514851
RefSeq - XM_006514860
RefSeq - XM_011243763
RefSeq - XM_011243764
RefSeq - XM_011243765
RefSeq Peptide - NP_001289560
RefSeq Peptide - NP_690031
RefSeq Peptide - NP_001289559
swissprot - Q5F210
swissprot - Q5QNQ4
swissprot - Q5QNQ6
swissprot - Q8K0C7
swissprot - Q5F209
Ensembl - ENSMUSG00000020435
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 osbp2ENSDARG00000053487Danio rerio
 si:ch211-106a19.1ENSDARG00000022772Danio rerio
 OSBP2ENSGALG00000007758Gallus gallus
 OSBP2ENSG00000184792Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Osbp / Q3B7Z2 / Oxysterol-binding protein 1 / P22059* / oxysterol binding protein*ENSMUSG0000002468752
Q91XL9 / Osbpl1a / Oxysterol-binding protein-related protein 1 / Q9BXW6* / oxysterol binding protein like 1A*ENSMUSG0000004425226
Osbpl3 / Q9DBS9 / Oxysterol-binding protein-related protein 3 / Q9H4L5* / oxysterol binding protein like 3*ENSMUSG0000002982225
Osbpl6 / Q8BXR9 / Oxysterol-binding protein-related protein 6 / Q9BZF3* / oxysterol binding protein like 6*ENSMUSG0000004235925
Osbpl7 / oxysterol binding protein like 7 / Q9BZF2*ENSMUSG0000003853422
Osbpl2 / Q8BX94 / Oxysterol-binding protein-related protein 2 / Q9H1P3* / oxysterol binding protein like 2*ENSMUSG0000003905018


Protein motifs (from Interpro)
Interpro ID Name
 IPR000648  Oxysterol-binding protein
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR018494  Oxysterol-binding protein, conserved site
 IPR037239  Oxysterol-binding protein superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0007286 spermatid development IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0097440 apical dendrite IDA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0015485 cholesterol binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
Show

Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0009833 absent sperm mitochondrial sheath "absence of the tightly packed helical sheath of ATP-producing mitochondria, normally found in the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

 MP:0009852 increased Sertoli cell phagocytosis "enhanced phagocytic activity of testicular Sertoli cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camk2atm1Kub/Camk2atm1Kub
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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