ENSMUSG00000020439


Mus musculus

Features
Gene ID: ENSMUSG00000020439
  
Biological name :Smtn
  
Synonyms : Q921U8 / Smoothelin / Smtn
  
Possible biological names infered from orthology : P53814
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 3517523
Gene end: 3540612
  
Corresponding Affymetrix probe sets: 10383731 (MoGene1.0st)   1452469_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105638
Ensembl peptide - ENSMUSP00000074621
Ensembl peptide - ENSMUSP00000117307
Ensembl peptide - ENSMUSP00000133155
Ensembl peptide - ENSMUSP00000118750
Ensembl peptide - ENSMUSP00000020718
Ensembl peptide - ENSMUSP00000020721
NCBI entrez gene - 29856     See in Manteia.
MGI - MGI:1354727
RefSeq - XM_017314587
RefSeq - NM_001159284
RefSeq - NM_001284427
RefSeq - NM_001284428
RefSeq - NM_001284429
RefSeq - NM_013870
RefSeq - XM_006514724
RefSeq - XM_017314586
RefSeq Peptide - NP_001152756
RefSeq Peptide - NP_001271357
RefSeq Peptide - NP_001271358
RefSeq Peptide - NP_038898
RefSeq Peptide - NP_001271356
swissprot - Q921U8
swissprot - D3Z525
swissprot - D3Z3Q3
swissprot - D3YZ10
swissprot - D3YVS1
Ensembl - ENSMUSG00000020439
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SMTNENSG00000183963Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8CI12 / Smtnl2 / Smoothelin-like protein 2 / Q2TAL5* / smoothelin like 2*ENSMUSG0000004566718
Q99LM3 / Smtnl1 / Smoothelin-like protein 1 / A8MU46* / smoothelin like 1*ENSMUSG0000002707714
Ehbp1l1 / EH domain-binding protein 1-like protein 1 isoform C / Q8N3D4* / EH domain binding protein 1 like 1*ENSMUSG0000002493711
Mical1 / Q8VDP3 / Mus musculus microtubule associated monooxygenase, calponin and LIM domain containing 1 (Mical1), transcript variant 4, mRNA. / Q8TDZ2* / microtubule associated monooxygen...ENSMUSG0000001982310
Q8BML1 / Mical2 / [F-actin]-monooxygenase MICAL2 / O94851* / Q6ZW33* / microtubule associated monooxygenase, calponin and LIM domain containing 2*ENSMUSG0000003824410
Mical3 / Q8CJ19 / [F-actin]-monooxygenase MICAL3 / Q7RTP6* / microtubule associated monooxygenase, calponin and LIM domain containing 3*ENSMUSG0000005158610
Ehbp1 / Q69ZW3 / EH domain-binding protein 1 / Q8NDI1*ENSMUSG000000423028
Q5SXY1 / Specc1 / sperm antigen with calponin homology and coiled-coil domains 1 / Q5M775*ENSMUSG000000423316
AC132392.1ENSMUSG000001111875
Q2KN98 / Specc1l / sperm antigen with calponin homology and coiled-coil domains 1-like / Q69YQ0* / SPECC1L-ADORA2A* / SPECC1L-ADORA2A readthrough (NMD candidate)*ENSMUSG000000334445
Q9D5U9 / Micalcl / MICAL C-terminal-like protein ENSMUSG000000307715
Q8BGT6 / Micall1 / MICAL-like protein 1 / Q8N3F8* / MICAL like 1*ENSMUSG000000330395
Q3TN34 / Micall2 / MICAL-like protein 2 / Q8IY33* / MICAL like 2*ENSMUSG000000367184


Protein motifs (from Interpro)
Interpro ID Name
 IPR001715  Calponin homology domain
 IPR022189  Smoothelin
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003085 negative regulation of systemic arterial blood pressure IMP
 biological_processGO:0060452 positive regulation of cardiac muscle contraction IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0003779 actin binding TAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000013 abnormal fat distribution "alterations in the normal placement and amount of body fat" [J:57315]
Show

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam10tm1.1Dhc/Adam10tm1.1Dhc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adam10tm1.1Dhc/Adam10tm1.1Dhc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Slc13a5M1Btlr/Slc13a5+
Genetic Background: C57BL/6J-Slc13a5M1Btlr

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Adam10tm1.1Dhc/Adam10tm1.1Dhc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hnf1btm2Mya/Hnf1btm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Adam10tm1.1Dhc/Adam10tm1.1Dhc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Smtntm2Gve/Smtntm2Gve
Genetic Background: B6.129-Smtntm2Gve

 MP:0003262 intestinal/bowel diverticulum "a pouch or sac protruding from the intestinal or bowel wall " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0003290 hypoperistalsis "reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Smtntm2Gve/Smtntm2Gve
Genetic Background: B6.129-Smtntm2Gve

 MP:0004002 abnormal jejunum morphology "malformation of the portion of the small intestine that extends from the duodenum to the ileum" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0004006 impaired contractility of jejunal smooth muscle "inability or reduced ability of the jejunal smoot muscle to shorter or to develop increased tension" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0004857 abnormal heart weight "anomaly in the average weight of the heart compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Smtntm2Gve/Smtntm2Gve
Genetic Background: B6.129-Smtntm2Gve

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Smtntm2Gve/Smtntm2Gve
Genetic Background: B6.129-Smtntm2Gve

 MP:0005044 sepsis "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434]
Show

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0006001 abnormal intestinal transit time "increase or decrease in the time it takes for a bolus of material to pass through the intestine" [smb:Susan M Bello, Mouse Genome Iformatics Curator]
Show

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0008843 absent subcutaneous adipose tissue "absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0011881 distended duodenum "an expansion in the volume of the portion of the small intestine that extends from the pyloris to the junction with the jejunum, as by stretching or distention" [MGI:Colin_McKerlie]
Show

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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