ENSMUSG00000033444


Mus musculus

Features
Gene ID: ENSMUSG00000033444
  
Biological name :Specc1l
  
Synonyms : Q2KN98 / Specc1l / sperm antigen with calponin homology and coiled-coil domains 1-like
  
Possible biological names infered from orthology : Q69YQ0 / SPECC1L-ADORA2A / SPECC1L-ADORA2A readthrough (NMD candidate)
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 75212073
Gene end: 75312743
  
Corresponding Affymetrix probe sets: 10364011 (MoGene1.0st)   1428300_at (Mouse Genome 430 2.0 Array)   1438581_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151552
Ensembl peptide - ENSMUSP00000045099
Ensembl peptide - ENSMUSP00000101061
Ensembl peptide - ENSMUSP00000151322
NCBI entrez gene - 74392     See in Manteia.
MGI - MGI:1921642
RefSeq - XM_017314127
RefSeq - NM_001145826
RefSeq - NM_153406
RefSeq - XM_006514252
RefSeq - XM_011243589
RefSeq Peptide - NP_700455
RefSeq Peptide - NP_001139298
swissprot - A0A1W2P785
swissprot - Q2KN98
swissprot - A0A0R4J0J8
Ensembl - ENSMUSG00000033444
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q2KN93ENSDARG00000006719Danio rerio
 specc1lbENSDARG00000042232Danio rerio
 SPECC1LENSGALG00000006648Gallus gallus
 Q69YQ0ENSG00000100014Homo sapiens
 SPECC1L-ADORA2AENSG00000258555Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5SXY1 / Specc1 / sperm antigen with calponin homology and coiled-coil domains 1 / Q5M775*ENSMUSG0000004233138
Mical3 / Q8CJ19 / [F-actin]-monooxygenase MICAL3 / Q7RTP6* / microtubule associated monooxygenase, calponin and LIM domain containing 3*ENSMUSG0000005158612
Mical1 / Q8VDP3 / Mus musculus microtubule associated monooxygenase, calponin and LIM domain containing 1 (Mical1), transcript variant 4, mRNA. / Q8TDZ2* / microtubule associated monooxygen...ENSMUSG000000198239
Q8BML1 / Mical2 / [F-actin]-monooxygenase MICAL2 / O94851* / Q6ZW33* / microtubule associated monooxygenase, calponin and LIM domain containing 2*ENSMUSG000000382449
Ehbp1l1 / EH domain-binding protein 1-like protein 1 isoform C / Q8N3D4* / EH domain binding protein 1 like 1*ENSMUSG000000249377
Q3TN34 / Micall2 / MICAL-like protein 2 / Q8IY33* / MICAL like 2*ENSMUSG000000367186
Q9D5U9 / Micalcl / MICAL C-terminal-like protein ENSMUSG000000307716
AC132392.1ENSMUSG000001111876
Q8BGT6 / Micall1 / MICAL-like protein 1 / Q8N3F8* / MICAL like 1*ENSMUSG000000330396
Ehbp1 / Q69ZW3 / EH domain-binding protein 1 / Q8NDI1*ENSMUSG000000423026
Smtn / Q921U8 / Smoothelin / P53814*ENSMUSG000000204394
Q8CI12 / Smtnl2 / Smoothelin-like protein 2 / Q2TAL5* / smoothelin like 2*ENSMUSG000000456673
Q99LM3 / Smtnl1 / Smoothelin-like protein 1 / A8MU46* / smoothelin like 1*ENSMUSG000000270772


Protein motifs (from Interpro)
Interpro ID Name
 IPR001715  Calponin homology domain
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007026 negative regulation of microtubule depolymerization IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007155 cell adhesion ISO
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0030036 actin cytoskeleton organization IMP
 biological_processGO:0030835 negative regulation of actin filament depolymerization IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060325 face morphogenesis ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IDA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005921 gap junction IEA
 cellular_componentGO:0015629 actin cytoskeleton ISO
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031941 filamentous actin IDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Specc1lGt(RRH048)Byg/Specc1lGt(RRH048)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Specc1lGt(RRH048)Byg/Specc1l+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Specc1lGt(RRH048)Byg/Specc1lGt(RRH048)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Specc1lGt(RRH048)Byg/Specc1l+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Ezh2tm2Sho/Ezh2tm2Sho,Olig1tm1(cre)Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Specc1lGt(DTM096)Byg/Specc1lGt(DTM096)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Specc1lGt(RRH048)Byg/Specc1lGt(RRH048)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ezh2tm2Sho/Ezh2tm2Sho,Olig1tm1(cre)Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Specc1lGt(DTM096)Byg/Specc1lGt(DTM096)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Specc1lGt(RRH048)Byg/Specc1lGt(RRH048)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Specc1lGt(RRH048)Byg/Specc1lGt(RRH048)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Specc1lGt(RRH048)Byg/Specc1l+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Ezh2tm2Sho/Ezh2tm2Sho,Olig1tm1(cre)Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Specc1lGt(DTM096)Byg/Specc1lGt(DTM096)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Specc1lGt(RRH048)Byg/Specc1lGt(RRH048)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012746 abnormal neural crest cell delamination "any anomaly in the process by which a neural crest cell (NCC) physically dissociates from the neuroepithelium in the dorsal aspect of the neural tube; premigratory NCCs exist within a fully polarized epithelial layer, adjoined by adherens junctions and tight junctions; NCC delamination involves an epithelial-mesenchymal transition (EMT) during which epithelial cells are converted into migratory mesenchymal cells; EMT requires loss of apical-basal cell polarity and dissolution of tight junctions and is accompanied by changes in cytoskeletal organization and a switch in adhesive properties so that cells can separate from the neuroepithelium and emigrate" [MGI:anna]
Show

Allelic Composition: Ezh2tm2Sho/Ezh2tm2Sho,Olig1tm1(cre)Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Specc1lGt(DTM096)Byg/Specc1lGt(DTM096)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Specc1lGt(RRH048)Byg/Specc1lGt(RRH048)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012757 abnormal cranial neural crest cell migration "any anomaly in the migratory path of the cranial neural crest cells (NCCs), which originate in the anterior part of the developing embryo and reside between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordial; like their counterparts in the trunk, cranial NCCs contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage" [MGI:anna]
Show

Allelic Composition: Ezh2tm2Sho/Ezh2tm2Sho,Olig1tm1(cre)Rth/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Specc1lGt(DTM096)Byg/Specc1lGt(DTM096)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Specc1lGt(RRH048)Byg/Specc1lGt(RRH048)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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