ENSMUSG00000020604


Mus musculus

Features
Gene ID: ENSMUSG00000020604
  
Biological name :Arsg
  
Synonyms : Arsg / Arylsulfatase G / Q3TYD4
  
Possible biological names infered from orthology : Q96EG1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 109473374
Gene end: 109573330
  
Corresponding Affymetrix probe sets: 10382271 (MoGene1.0st)   1427002_s_at (Mouse Genome 430 2.0 Array)   1452277_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020928
Ensembl peptide - ENSMUSP00000102307
Ensembl peptide - ENSMUSP00000102308
NCBI entrez gene - 74008     See in Manteia.
MGI - MGI:1921258
RefSeq - XM_017314803
RefSeq - NM_001166177
RefSeq - NM_028710
RefSeq - XM_017314800
RefSeq - XM_017314801
RefSeq - XM_017314802
RefSeq - XM_006534348
RefSeq - XM_006534349
RefSeq - XM_006534350
RefSeq Peptide - NP_082986
RefSeq Peptide - NP_001159649
swissprot - Q3TYD4
Ensembl - ENSMUSG00000020604
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arsgENSDARG00000101715Danio rerio
 ARSGENSGALG00000004193Gallus gallus
 ARSGENSG00000141337Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arsa / P50428 / Arylsulfatase A / P15289*ENSMUSG0000002262035
Galns / Q571E4 / N-acetylgalactosamine-6-sulfatase / P34059* / galactosamine (N-acetyl)-6-sulfatase*ENSMUSG0000001502733
Arsi / Q32KI9 / Arylsulfatase I / Q5FYB1* / arylsulfatase family member I*ENSMUSG0000003641224
Arsj / Q8BM89 / Arylsulfatase J / Q5FYB0* / arylsulfatase family member J*ENSMUSG0000004656123
Arsb / arylsulfatase B / P15848*ENSMUSG0000004208222


Protein motifs (from Interpro)
Interpro ID Name
 IPR000917  Sulfatase, N-terminal
 IPR017849  Alkaline phosphatase-like, alpha/beta/alpha
 IPR017850  Alkaline-phosphatase-like, core domain superfamily
 IPR024607  Sulfatase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006790 sulfur compound metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004065 arylsulfatase activity ISS
 molecular_functionGO:0008484 sulfuric ester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism
The activation of arylsulfatases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
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Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0004967 abnormal kidney epithelium morphology "any structural anomaly of the cellular avascular layer of the kidney luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptentm1Rdp/Ptentm1Rdp,Tg(tetO-BRAF*V600E)29Lc/0,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

 MP:0005059 lysosomal protein accumulation "buildup of protein in the lysosome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptentm1Rdp/Ptentm1Rdp,Tg(tetO-BRAF*V600E)29Lc/0,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

 MP:0008242 abnormal perivascular macrophage morphology "any structural anomaly of macrophages that line the small blood vessels" [PMID:16322748]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0008989 abnormal liver sinusoid morphology "any structural anomaly of the hepatic distensible vascular blood channels lined with highly fenestrated endothelial cells that function to exchange fluids, nutrients, proteins and wastes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0009939 abnormal hippocampus neuron morphology 
Show

Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0010369 abnormal thalamus neuron morphology "any structural anomaly of the impulse-conducting cells in the thalamus or its parts, a midline paired symmetrical structure between the cerebral cortex and midbrain within the brain that controls the flow of information to the cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0011475 abnormal glycosaminoglycan level "any change in the amount of glycosaminoglycan, including chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin sulfate, heparin, and/or hyaluronan and other long unbranched polysaccharides consisting of a repeating disaccharide unit" [MGI:csmith]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Ctnnb1tm1Wvv/Ctnnb1+,Tg(Fabp1-cre)1Jig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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