| MP:0000136 | abnormal microglial cell morphology | "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
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| MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
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| MP:0000876 | Purkinje cell degeneration | "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
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| MP:0000877 | abnormal Purkinje cell | "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
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| MP:0000889 | abnormal cerebellar molecular layer | "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
|
| MP:0000920 | abnormal myelination | "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
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| MP:0000921 | demyelination | "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
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| MP:0001106 | abnormal Schwann cell | "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
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| MP:0001393 | ataxia | "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
|
| MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Arsatm1Gie/Arsatm1Gie
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
|
| MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
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| MP:0001407 | short stride length | "reduced average distance between steps" [J:34193] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
|
| MP:0001463 | abnormal spatial learning | "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
Allelic Composition: Arsatm1Gie/Arsatm1Gie
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0001522 | impaired swimming | "reduced ability or inability to swim" [J:45446, J:39081] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
Allelic Composition: Arsatm1Gie/Arsatm1Gie
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001525 | impaired balance | "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123] |
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Allelic Composition: Arsatm1Gie/Arsatm1Gie
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0001967 | deafness | "inability to hear" [J:57651] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
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| MP:0002118 | abnormal lipid homeostasis | "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
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| MP:0002799 | abnormal passive avoidance behavior | "defects in the ability of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously with prolonged latency" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Arsatm1Gie/Arsatm1Gie
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0002856 | abnormal vestibular ganglion morphology | "malformation of the group of neurons associated with the vestibular part of the eighth cranial nerve that are involved in equilibration" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
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| MP:0002857 | cochlear ganglion degeneration | "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
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| MP:0002882 | abnormal neuron | "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
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| MP:0003354 | astrocytosis | "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
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| MP:0005404 | abnormal axon morphology | "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
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| MP:0008026 | abnormal brain white matter morphology | "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
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| MP:0008128 | abnormal brain internal capsule morphology | "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
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| MP:0011967 | increased or absent threshold for auditory brainstem response | "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith] |
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Allelic Composition: Hephsla/Hephsla
Genetic Background: involves: C57BL/6J
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