ENSMUSG00000015027


Mus musculus

Features
Gene ID: ENSMUSG00000015027
  
Biological name :Galns
  
Synonyms : Galns / N-acetylgalactosamine-6-sulfatase / Q571E4
  
Possible biological names infered from orthology : galactosamine (N-acetyl)-6-sulfatase / P34059
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E1
Gene start: 122578242
Gene end: 122611463
  
Corresponding Affymetrix probe sets: 10582403 (MoGene1.0st)   1443753_at (Mouse Genome 430 2.0 Array)   1448744_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015171
Ensembl peptide - ENSMUSP00000148591
NCBI entrez gene - 50917     See in Manteia.
MGI - MGI:1355303
RefSeq - XM_017312895
RefSeq - NM_001193645
RefSeq - NM_016722
RefSeq - XM_006531177
RefSeq - XM_017312894
RefSeq Peptide - NP_001180574
RefSeq Peptide - NP_057931
swissprot - Q8CC47
swissprot - Q571E4
Ensembl - ENSMUSG00000015027
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 galnsENSDARG00000051853Danio rerio
 GALNSENSGALG00000039673Gallus gallus
 GALNSENSG00000141012Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arsa / P50428 / Arylsulfatase A / P15289*ENSMUSG0000002262033
Arsg / Q3TYD4 / Arylsulfatase G / Q96EG1*ENSMUSG0000002060433
Arsi / Q32KI9 / Arylsulfatase I / Q5FYB1* / arylsulfatase family member I*ENSMUSG0000003641224
Arsj / Q8BM89 / Arylsulfatase J / Q5FYB0* / arylsulfatase family member J*ENSMUSG0000004656124
Arsb / arylsulfatase B / P15848*ENSMUSG0000004208224


Protein motifs (from Interpro)
Interpro ID Name
 IPR000917  Sulfatase, N-terminal
 IPR017849  Alkaline phosphatase-like, alpha/beta/alpha
 IPR017850  Alkaline-phosphatase-like, core domain superfamily
 IPR024607  Sulfatase, conserved site
 IPR035626  N-acetylgalactosamine-6-sulfatase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005764 lysosome IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0008484 sulfuric ester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043890 N-acetylgalactosamine-6-sulfatase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Keratan sulfate degradation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cenpbtm1Khac/Cenpbtm1Khac
Genetic Background: B6.129-Cenpbtm1Khac

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lmx1bIcst/Lmx1b+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Galnstm2(GALNS)Toma/Galnstm2(GALNS)Toma
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Galnstm2(GALNS)Toma/Galnstm2(GALNS)Toma
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003172 abnormal lysosome physiology "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Lmx1bIcst/Lmx1b+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Galnstm2(GALNS)Toma/Galnstm2(GALNS)Toma
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Galnstm2(GALNS)Toma/Galnstm2(GALNS)Toma
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005059 lysosomal protein accumulation "buildup of protein in the lysosome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Galnstm2(GALNS)Toma/Galnstm2(GALNS)Toma
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Galnstm3Toma/Galnstm3Toma
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Galnstm2(GALNS)Toma/Galnstm2(GALNS)Toma
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011473 increased urine glycosaminoglycan level "greater in the amount of glycosaminoglycan in the urine, including chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin sulfate, heparin, and/or hyaluronan and other long unbranched polysaccharides consisting of a repeating disaccharide unit" [MGI:csmith]
Show

Allelic Composition: Lmx1bIcst/Lmx1b+
Genetic Background: involves: BALB/cAnN * C3H/HeN

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015027 Galns / Q571E4 / N-acetylgalactosamine-6-sulfatase / P34059* / galactosamine (N-acetyl)-6-sulfatase*  / -






 

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