ENSMUSG00000020614


Mus musculus

Features
Gene ID: ENSMUSG00000020614
  
Biological name :Fam20a
  
Synonyms : Fam20a / Pseudokinase FAM20A / Q8CID3
  
Possible biological names infered from orthology : FAM20A, golgi associated secretory pathway pseudokinase / Q96MK3
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 109669749
Gene end: 109722279
  
Corresponding Affymetrix probe sets: 10392464 (MoGene1.0st)   1433653_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020938
Ensembl peptide - ENSMUSP00000116687
NCBI entrez gene - 208659     See in Manteia.
MGI - MGI:2388266
RefSeq - XM_006532724
RefSeq - NM_153782
RefSeq Peptide - NP_722477
swissprot - Q8CID3
Ensembl - ENSMUSG00000020614
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fam20aENSDARG00000079486Danio rerio
 FAM20AENSGALG00000040655Gallus gallus
 FAM20AENSG00000108950Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fam20c / Q5MJS3 / Extracellular serine/threonine protein kinase FAM20C / Q8IXL6* / FAM20C, golgi associated secretory pathway kinase*ENSMUSG0000002585443
Fam20b / Q8VCS3 / Glycosaminoglycan xylosylkinase / O75063* / FAM20B, glycosaminoglycan xylosylkinase*ENSMUSG0000003355729


Protein motifs (from Interpro)
Interpro ID Name
 IPR009581  FAM20, C-terminal
 IPR024869  FAM20


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0031214 biomineral tissue development ISO
 biological_processGO:0044691 tooth eruption IEA
 biological_processGO:0055074 calcium ion homeostasis IEA
 biological_processGO:0070166 enamel mineralization IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002576 abnormal enamel morphology "malformation of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002649 abnormal enamel rod pattern "anomalous orientation of the structural unit of tooth enamel " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002650 abnormal ameloblast morphology "malformation of the epithelial cells of the inner layer of the enamel organ of the developing tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002689 abnormal molar morphology "structural defect of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [il:Ira Lu , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0003404 absent enamel "absence of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:92017]
Show

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0006133 arterial calcification "pathologic deposition of calcium salts in the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0006402 small molars "reduced size of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0010923 pulmonary alveolar calcification "pathologic deposition of calcium salts in the pulmonary alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011309 abnormal kidney arterial blood vessel morphology "any structural anomaly of the network of tubes that supply blood to the renal tissues" [MGI:csmith]
Show

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0030138 abnormal lower incisor color "anomaly in the color and shading of the lower incisors, which normally presents in shades of white" [MGI:anna]
Show

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0030139 abnormal upper incisor color "anomaly in the color and shading of the upper incisors, which normally presents in shades of white" [MGI:anna]
Show

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0030457 abnormal molar cusp morphology "any structural anomaly of an elevation or mound on the crown of a molar tooth making up a part of the occlusal (masticatory) surface" [https://medical-dictionary.thefreedictionary.com/cusp+of+tooth, MGI:anna]
Show

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0030458 abnormal tooth wear "change in the progression or severity of loss of tooth substance, usually resulting from abrasion, attrition and erosion acting singly or concurrently; tooth wear is a normal, age-dependent physiological process that leads to surface loss of dental hard tissues" [https://www.igi-global.com/dictionary/tooth-wear/45534, https://www.slideshare.net/aneeqa_yaqub/tooth-wear-and-its-types, PMID:22240686]
Show

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0030460 enamel pits "presence of small depressions in the dental enamel" [HP:0009722]
Show

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0030500 conical molar "a molar tooth whose sides converge or taper together incisally forming a peg-shaped (coniform) crown" [MGI:anna]
Show

Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025854 Fam20c / Q5MJS3 / Extracellular serine/threonine protein kinase FAM20C / Q8IXL6* / FAM20C, golgi associated secretory pathway kinase*  / complex






 

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