ENSMUSG00000020630


Mus musculus

Features
Gene ID: ENSMUSG00000020630
  
Biological name :Rnaseh1
  
Synonyms : ribonuclease H1 isoform 2 / Rnaseh1
  
Possible biological names infered from orthology : AC108488.2
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A2
Gene start: 28649602
Gene end: 28659589
  
Corresponding Affymetrix probe sets: 10395049 (MoGene1.0st)   1453833_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020959
Ensembl peptide - ENSMUSP00000152845
NCBI entrez gene - 19819     See in Manteia.
MGI - MGI:1335073
RefSeq - NM_001286865
RefSeq - NM_011275
RefSeq Peptide - NP_001273794
RefSeq Peptide - NP_035405
swissprot - E9QLN8
swissprot - A0A1Y7VM77
Ensembl - ENSMUSG00000020630
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnaseh1ENSDARG00000042571Danio rerio
 RNASEH1ENSGALG00000016389Gallus gallus
 AC108488.2ENSG00000255767Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002156  Ribonuclease H domain
 IPR009027  Ribosomal protein L9/RNase H1, N-terminal
 IPR011320  Ribonuclease H1, N-terminal
 IPR012337  Ribonuclease H-like superfamily
 IPR017067  Ribonuclease H1, eukaryote
 IPR036397  Ribonuclease H superfamily
 IPR037056  Ribonuclease H1, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004523 RNA-DNA hybrid ribonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0011630 increased mitochondria size "enlarged the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0011636 disorganized mitochondrial cristae "derangement of the pattern of the inward folds of the mitochondrial inner membrane" [MGI:csmith]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0011639 decreased mitochondrial DNA content "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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