ENSMUSG00000020694


Mus musculus

Features
Gene ID: ENSMUSG00000020694
  
Biological name :Tlk2
  
Synonyms : O55047 / Serine/threonine-protein kinase tousled-like 2 / Tlk2
  
Possible biological names infered from orthology : Q86UE8 / tousled like kinase 2
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 105178807
Gene end: 105283959
  
Corresponding Affymetrix probe sets: 10381872 (MoGene1.0st)   1416944_a_at (Mouse Genome 430 2.0 Array)   1429999_at (Mouse Genome 430 2.0 Array)   1431827_a_at (Mouse Genome 430 2.0 Array)   1454018_at (Mouse Genome 430 2.0 Array)   1457357_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118520
Ensembl peptide - ENSMUSP00000102554
Ensembl peptide - ENSMUSP00000120944
Ensembl peptide - ENSMUSP00000123179
Ensembl peptide - ENSMUSP00000121897
Ensembl peptide - ENSMUSP00000015107
Ensembl peptide - ENSMUSP00000090198
Ensembl peptide - ENSMUSP00000102552
NCBI entrez gene - 24086     See in Manteia.
MGI - MGI:1346023
RefSeq - XM_017314552
RefSeq - NM_001294331
RefSeq - NM_001294334
RefSeq - XM_006533312
RefSeq - XM_006533313
RefSeq - XM_006533314
RefSeq - XM_006533315
RefSeq - XM_006533316
RefSeq - XM_006533320
RefSeq - XM_011249014
RefSeq - XM_017314550
RefSeq - XM_017314551
RefSeq - NM_001112705
RefSeq - NM_001294329
RefSeq - NM_001294330
RefSeq Peptide - NP_001281258
RefSeq Peptide - NP_001281259
RefSeq Peptide - NP_001281260
RefSeq Peptide - NP_001281263
RefSeq Peptide - NP_001106176
swissprot - B1ASU9
swissprot - D6RHM1
swissprot - B7ZC85
swissprot - F6XSD0
swissprot - B7ZC84
swissprot - O55047
Ensembl - ENSMUSG00000020694
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLK2ENSGALG00000000410Gallus gallus
 TLK2ENSG00000146872Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tlk1 / Q8C0V0 / Serine/threonine-protein kinase tousled-like 1 / Q9UKI8* / tousled like kinase 1*ENSMUSG0000004199771
Ttk / P35761 / Ttk protein kinase / P33981*ENSMUSG0000003837915


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR027086  Serine/threonine-protein kinase TOUSLED-like 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001672 regulation of chromatin assembly or disassembly ISO
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0071480 cellular response to gamma radiation ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005882 intermediate filament ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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