ENSMUSG00000038379


Mus musculus

Features
Gene ID: ENSMUSG00000038379
  
Biological name :Ttk
  
Synonyms : P35761 / Ttk / Ttk protein kinase
  
Possible biological names infered from orthology : P33981
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E2
Gene start: 83834689
Gene end: 83872389
  
Corresponding Affymetrix probe sets: 10587508 (MoGene1.0st)   1442594_at (Mouse Genome 430 2.0 Array)   1449171_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064839
Ensembl peptide - ENSMUSP00000139900
Ensembl peptide - ENSMUSP00000139956
NCBI entrez gene - 22137     See in Manteia.
MGI - MGI:1194921
RefSeq - XM_006511060
RefSeq - NM_001110265
RefSeq - NM_001284272
RefSeq - NM_009445
RefSeq - XM_006511058
RefSeq - XM_006511059
RefSeq Peptide - NP_033471
RefSeq Peptide - NP_001103735
RefSeq Peptide - NP_001271201
swissprot - P35761
swissprot - Q3TPW2
swissprot - A0A087WPS8
Ensembl - ENSMUSG00000038379
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ttkENSDARG00000041361Danio rerio
 TTKENSGALG00000015874Gallus gallus
 TTKENSG00000112742Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tlk2 / O55047 / Serine/threonine-protein kinase tousled-like 2 / Q86UE8* / tousled like kinase 2*ENSMUSG0000002069414
Tlk1 / Q8C0V0 / Serine/threonine-protein kinase tousled-like 1 / Q9UKI8* / tousled like kinase 1*ENSMUSG0000004199714


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR027084  Protein kinase Mps1 family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016321 female meiosis chromosome segregation IMP
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0033316 meiotic spindle assembly checkpoint IMP
 biological_processGO:0034501 protein localization to kinetochore IMP
 biological_processGO:0034502 protein localization to chromosome IMP
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0051304 chromosome separation IEA
 biological_processGO:1903096 protein localization to meiotic spindle midzone IMP
 cellular_componentGO:0000776 kinetochore IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane ISM
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0009769 abnormal meiotic spindle assembly checkpoint "an anomaly in the process that normally prevents inaccurate segregation of chromosomes by inhibiting cell-cycle progression in response to a signal generated by meiotic spindle damage or by chromosomes that have not attached to microtubules" [PMID:18596218]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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