ENSG00000112742


Homo sapiens

Features
Gene ID: ENSG00000112742
  
Biological name :TTK
  
Synonyms : P33981 / TTK / TTK protein kinase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q14.1
Gene start: 80003887
Gene end: 80042527
  
Corresponding Affymetrix probe sets: 204822_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421406
Ensembl peptide - ENSP00000421636
Ensembl peptide - ENSP00000487202
Ensembl peptide - ENSP00000427483
Ensembl peptide - ENSP00000424851
Ensembl peptide - ENSP00000422936
Ensembl peptide - ENSP00000230510
Ensembl peptide - ENSP00000358813
NCBI entrez gene - 7272     See in Manteia.
OMIM - 604092
RefSeq - NM_003318
RefSeq - XM_017011242
RefSeq - XM_011536100
RefSeq - XM_011536099
RefSeq - NM_001166691
RefSeq Peptide - NP_001160163
RefSeq Peptide - NP_003309
swissprot - D6RFY1
swissprot - P33981
swissprot - D6REX1
swissprot - D6RF82
swissprot - D6RIC6
Ensembl - ENSG00000112742
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ttkENSDARG00000041361Danio rerio
 TTKENSGALG00000015874Gallus gallus
 TtkENSMUSG00000038379Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLK1 / Q9UKI8 / tousled like kinase 1ENSG0000019858615
TLK2 / Q86UE8 / tousled like kinase 2ENSG0000014687214


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR027084  Protein kinase Mps1 family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007051 spindle organization TAS
 biological_processGO:0007052 mitotic spindle organization TAS
 biological_processGO:0007093 mitotic cell cycle checkpoint IEA
 biological_processGO:0007094 mitotic spindle assembly checkpoint TAS
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016321 female meiosis chromosome segregation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0033316 meiotic spindle assembly checkpoint IEA
 biological_processGO:0034501 protein localization to kinetochore IEA
 biological_processGO:0034502 protein localization to chromosome IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051304 chromosome separation IEA
 biological_processGO:1903096 protein localization to meiotic spindle midzone IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005819 spindle TAS
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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