ENSG00000146872


Homo sapiens

Features
Gene ID: ENSG00000146872
  
Biological name :TLK2
  
Synonyms : Q86UE8 / TLK2 / tousled like kinase 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q23.2
Gene start: 62458658
Gene end: 62615481
  
Corresponding Affymetrix probe sets: 212986_s_at (Human Genome U133 Plus 2.0 Array)   212997_s_at (Human Genome U133 Plus 2.0 Array)   228627_at (Human Genome U133 Plus 2.0 Array)   233349_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464557
Ensembl peptide - ENSP00000463986
Ensembl peptide - ENSP00000464516
Ensembl peptide - ENSP00000275780
Ensembl peptide - ENSP00000316512
Ensembl peptide - ENSP00000340800
Ensembl peptide - ENSP00000462036
Ensembl peptide - ENSP00000462637
Ensembl peptide - ENSP00000462851
Ensembl peptide - ENSP00000463595
Ensembl peptide - ENSP00000463814
NCBI entrez gene - 11011     See in Manteia.
OMIM - 608439
RefSeq - XM_017024060
RefSeq - XM_017024047
RefSeq - XM_017024048
RefSeq - XM_017024049
RefSeq - XM_017024050
RefSeq - XM_017024051
RefSeq - XM_017024052
RefSeq - XM_017024053
RefSeq - XM_017024054
RefSeq - XM_017024055
RefSeq - XM_017024056
RefSeq - XM_017024057
RefSeq - XM_017024058
RefSeq - XM_017024059
RefSeq - NM_001284333
RefSeq - NM_001284363
RefSeq - NM_006852
RefSeq - XM_011524215
RefSeq - XM_011524216
RefSeq - XM_011524217
RefSeq - XM_011524218
RefSeq - XM_011524220
RefSeq - XM_011524221
RefSeq - XM_011524222
RefSeq - XM_011524223
RefSeq - XM_011524224
RefSeq - XM_011524225
RefSeq - XM_011524226
RefSeq - XM_011524227
RefSeq - XM_011524228
RefSeq - XM_011524229
RefSeq - XM_011524231
RefSeq - XM_017024044
RefSeq - XM_017024045
RefSeq - XM_017024046
RefSeq Peptide - NP_006843
RefSeq Peptide - NP_001271262
RefSeq Peptide - NP_001271292
RefSeq Peptide - NP_001317347
swissprot - J3QR10
swissprot - J3QS44
swissprot - J3KST4
swissprot - Q86UE8
swissprot - J3KRK0
swissprot - J3QS73
swissprot - J3KT82
swissprot - J3QLK5
swissprot - J3QQN4
Ensembl - ENSG00000146872
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLK2ENSGALG00000000410Gallus gallus
 Tlk2ENSMUSG00000020694Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLK1 / Q9UKI8 / tousled like kinase 1ENSG0000019858670
TTK / P33981 / TTK protein kinaseENSG0000011274216


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR027086  Serine/threonine-protein kinase TOUSLED-like 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001672 regulation of chromatin assembly or disassembly IDA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IMP
 biological_processGO:0010507 negative regulation of autophagy NAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0071480 cellular response to gamma radiation IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005882 intermediate filament IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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