ENSMUSG00000020738


Mus musculus

Features
Gene ID: ENSMUSG00000020738
  
Biological name :Sumo2
  
Synonyms : P61957 / small ubiquitin-like modifier 2 / Sumo2
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 115523102
Gene end: 115536276
  
Corresponding Affymetrix probe sets: 10353219 (MoGene1.0st)   10392947 (MoGene1.0st)   10438454 (MoGene1.0st)   10484351 (MoGene1.0st)   10520124 (MoGene1.0st)   1415781_a_at (Mouse Genome 430 2.0 Array)   1415782_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113108
Ensembl peptide - ENSMUSP00000115044
Ensembl peptide - ENSMUSP00000113883
Ensembl peptide - ENSMUSP00000021084
Ensembl peptide - ENSMUSP00000112594
NCBI entrez gene - 170930     See in Manteia.
MGI - MGI:2158813
RefSeq - NM_133354
RefSeq Peptide - NP_579932
swissprot - D3YW94
swissprot - H7BWX9
swissprot - D3Z794
swissprot - P61957
Ensembl - ENSMUSG00000020738
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6DHL4ENSDARG00000102741Danio rerio
 SUMO2ENSGALG00000007971Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*ENSMUSG0000002026595
Sumo3ENSMUSG0000011224176
Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*ENSMUSG0000002602153


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR022617  Rad60/SUMO-like domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR033950  Sumo domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016925 protein sumoylation ISO
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0016605 PML body ISS
 molecular_functionGO:0001222 transcription corepressor binding ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019789 SUMO transferase activity IDA
 molecular_functionGO:0031386 protein tag IBA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Sumo2tm1Weiy/Sumo2+,Sumo3tm1Weiy/Sumo3+
Genetic Background: involves: 129 * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

Allelic Composition: Sumo2tm1Weiy/Sumo2+,Sumo3tm1Weiy/Sumo3+
Genetic Background: involves: 129 * C57BL/6

 MP:0003794 delayed somite formation "late onset of the induction and/or differentiation of the somites" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:99723]
Show

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0005030 absent amnion "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0006323 abnormal extraembryonic mesoderm development "malformation of the mesoderm of the extraembryonic tissue that is involved in forming the amnion, chorion,yolk sac, and body stalk" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0009656 delayed chorioallantoic fusion "late onset of the initiation and/or completion of the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sumo2tm1Weiy/Sumo2+,Sumo3tm1Weiy/Sumo3+
Genetic Background: involves: 129 * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Sumo2tm1Weiy/Sumo2+,Sumo3tm1Weiy/Sumo3+
Genetic Background: involves: 129 * C57BL/6

 MP:0012082 delayed heart development "late onset of the induction and/or differentiation of the heart" [MGI:anna]
Show

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020265 Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*  / -
 ENSMUSG00000020738 Sumo2 / P61957 / small ubiquitin-like modifier 2  / -
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / complex






 

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