ENSMUSG00000020777


Mus musculus

Features
Gene ID: ENSMUSG00000020777
  
Biological name :Acox1
  
Synonyms : Acox1 / Peroxisomal acyl-coenzyme A oxidase 1 / Q9R0H0
  
Possible biological names infered from orthology : acyl-CoA oxidase 1 / Q15067
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 116171888
Gene end: 116199045
  
Corresponding Affymetrix probe sets: 10393177 (MoGene1.0st)   1416408_at (Mouse Genome 430 2.0 Array)   1416409_at (Mouse Genome 430 2.0 Array)   1444518_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063325
Ensembl peptide - ENSMUSP00000072717
Ensembl peptide - ENSMUSP00000122185
NCBI entrez gene - 11430     See in Manteia.
MGI - MGI:1330812
RefSeq - XM_006532002
RefSeq - NM_001271898
RefSeq - NM_015729
RefSeq Peptide - NP_001258827
RefSeq Peptide - NP_056544
swissprot - Q9R0H0
swissprot - A2A848
Ensembl - ENSMUSG00000020777
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acox1ENSDARG00000014727Danio rerio
 ACOX1ENSGALG00000002159Gallus gallus
 ACOX1ENSG00000161533Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acox2 / Q9QXD1 / Peroxisomal acyl-coenzyme A oxidase 2 / Q99424* / acyl-CoA oxidase 2*ENSMUSG0000002175144
Acox3 / Q9EPL9 / Mus musculus acyl-Coenzyme A oxidase 3, pristanoyl (Acox3), transcript variant 3, mRNA. / O15254* / acyl-CoA oxidase 3, pristanoyl*ENSMUSG0000002909830
Acoxl / Q9DBS4 / Acyl-coenzyme A oxidase-like protein / Q9NUZ1* / acyl-CoA oxidase like*ENSMUSG0000002738025


Protein motifs (from Interpro)
Interpro ID Name
 IPR002655  Acyl-CoA oxidase, C-terminal
 IPR006091  Acyl-CoA oxidase/dehydrogenase, central domain
 IPR009100  Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
 IPR012258  Acyl-CoA oxidase
 IPR029320  Acyl-coenzyme A oxidase, N-terminal
 IPR034171  Peroxisomal acyl-coenzyme A oxidase
 IPR036250  Acyl-CoA dehydrogenase-like, C-terminal
 IPR037069  Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000038 very long-chain fatty acid metabolic process IEA
 biological_processGO:0006091 generation of precursor metabolites and energy IEA
 biological_processGO:0006629 lipid metabolic process ISO
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006635 fatty acid beta-oxidation TAS
 biological_processGO:0006693 prostaglandin metabolic process IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016559 peroxisome fission ISO
 biological_processGO:0019395 fatty acid oxidation IEA
 biological_processGO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
 biological_processGO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase ISO
 biological_processGO:0055088 lipid homeostasis ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005777 peroxisome TAS
 cellular_componentGO:0005778 peroxisomal membrane IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003995 acyl-CoA dehydrogenase activity IBA
 molecular_functionGO:0003997 acyl-CoA oxidase activity TAS
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0016401 palmitoyl-CoA oxidase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IBA
 molecular_functionGO:0071949 FAD binding ISO


Pathways (from Reactome)
Pathway description
alpha-linolenic acid (ALA) metabolism
Beta-oxidation of very long chain fatty acids
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4tm1Yau,Pou4f2tm4Whk/Pou4f2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4tm1Yau,Pou4f2tm4Whk/Pou4f2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4tm1Yau,Pou4f2tm4Whk/Pou4f2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001548 hyperlipidemia "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4tm1Yau,Pou4f2tm4Whk/Pou4f2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4tm1Yau,Pou4f2tm4Whk/Pou4f2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Opn4tm1.1(cre)Saha/Opn4tm1Yau,Pou4f2tm4Whk/Pou4f2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Acox1lampe1/Acox1lampe1
Genetic Background: involves: C57BL/6J

 MP:0002658 abnormal liver regeneration "deviation from the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Acox1lampe1/Acox1lampe1
Genetic Background: involves: C57BL/6J

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Acox1lampe1/Acox1lampe1
Genetic Background: involves: C57BL/6J

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Acox1lampe1/Acox1lampe1
Genetic Background: involves: C57BL/6J

 MP:0005536 Leydig cell hypoplasia "reduced numbers of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0010264 increased hepatoma incidence "greater than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldb3tm3Chen/Ldb3tm3Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005069 Pex5 / O09012 / Peroxisomal targeting signal 1 receptor / P50542* / peroxisomal biogenesis factor 5*  / reaction / complex
 ENSMUSG00000020777 Acox1 / Q9R0H0 / Peroxisomal acyl-coenzyme A oxidase 1 / Q15067* / acyl-CoA oxidase 1*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr