ENSMUSG00000020810


Mus musculus

Features
Gene ID: ENSMUSG00000020810
  
Biological name :Cygb
  
Synonyms : Cygb / Cytoglobin / Q9CX80
  
Possible biological names infered from orthology : Q8WWM9
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 116645595
Gene end: 116654313
  
Corresponding Affymetrix probe sets: 10393364 (MoGene1.0st)   1423630_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021166
NCBI entrez gene - 114886     See in Manteia.
MGI - MGI:2149481
RefSeq - XM_011248674
RefSeq - NM_030206
RefSeq Peptide - NP_084482
swissprot - Q546K1
swissprot - Q9CX80
Ensembl - ENSMUSG00000020810
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cygb1ENSDARG00000099371Danio rerio
 cygb2ENSDARG00000070148Danio rerio
 CYGBENSGALG00000001892Gallus gallus
 CYGBENSG00000161544Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mb / P04247 / myoglobin / P02144*ENSMUSG0000001889322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000971  Globin
 IPR009050  Globin-like superfamily
 IPR013314  Globin, lamprey/hagfish type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0010764 negative regulation of fibroblast migration IEA
 biological_processGO:0015671 oxygen transport IEA
 biological_processGO:0019395 fatty acid oxidation IEA
 biological_processGO:0032966 negative regulation of collagen biosynthetic process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:2000490 negative regulation of hepatic stellate cell activation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0004096 catalase activity IEA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0005344 oxygen carrier activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0019825 oxygen binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047888 fatty acid peroxidase activity IEA


Pathways (from Reactome)
Pathway description
eNOS activation
Intracellular oxygen transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gjb1tm1Kwi/Y,Gjc2tm2.1Kwi/Gjc2tm2.1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gjb1tm1Kwi/Y,Gjc2tm2.1Kwi/Gjc2tm2.1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Cygbtm1Nka/Cygb+
Genetic Background: B6.Cg-Cygbtm1Nka

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gjb1tm1Kwi/Y,Gjc2tm2.1Kwi/Gjc2tm2.1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Cygbtm1Nka/Cygb+
Genetic Background: B6.Cg-Cygbtm1Nka

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gjb1tm1Kwi/Y,Gjc2tm2.1Kwi/Gjc2tm2.1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0009415 skeletal muscle degeneration "pathological deterioration of skeletal muscle tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0010639 altered tumor pathology "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gjb1tm1Kwi/Y,Gjc2tm2.1Kwi/Gjc2tm2.1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011808 abnormal myoblast differentiation "anomaly in the process in which a relatively unspecialized cell acquires specialized features of a myoblast, a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers" [GO:0045445]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0012186 abnormal muscle precursor cell physiology "anomaly in the function of cells that will develop into muscle cells" [MGI:mnk]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0013160 impaired muscle regeneration "inability, defects in ability or delayed ability to repair muscle after injury or disease" [MGI:csmith]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020810 Cygb / Q9CX80 / Cytoglobin / Q8WWM9*  / complex






 

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